An evaluation and comparison of Reflolux II and Glucometer II, two new portable reflectance meters for capillary blood glucose determination

Schier, G. M.; Moses, Robert G.; Gan, I.E.T.; Blair, S.C.

doi:10.1016/s0168-8227(88)80015-9

Cited by 39 publications

(18 citation statements)

References 10 publications

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“…Interestingly, the pKa of the glucose bound forms are substantially reduced, pKa 6 → 7, as compared to typical BAFs reported in the literature, pKa's usually 7. This reduction in probe-bound sugar pKa affords for a substantial sugar response in the contact lens polymers studied here, 5 which we have shown have an 5 See FN4. internal pH in the range 5.5-6.5 and a lens polarity similar to that of methanol [27].…”

Section: Introductionmentioning

confidence: 72%

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A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Badugu

Lakowicz

Geddes

2003

Journal of Fluorescence

107

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We have developed a range of glucose sensing contact lenses, using a daily, disposable contact lens embedded with newly developed boronic acid containing fluorophores. Our findings show that our approach may be suitable for the continuous monitoring of tear glucose levels in the range 50-1000 µM, which typically track blood glucose levels, which are ≈5-10 fold higher. Our non-invasive approach may well offer an alternative solution to current invasive glucose monitoring techniques for diabetes, such as "finger pricking."

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Section: Introductionmentioning

confidence: 72%

“…The first one is inconvenience and the required compliance by patients, while the second is that this is not a continuous monitoring method. Despite intensive efforts [1][2][3][4][5][6][7][8][9][10][11], no method is currently available for the continuous non-invasive monitoring of blood glucose.…”

Section: Introductionmentioning

confidence: 99%

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Badugu

Lakowicz

Geddes

2003

Journal of Fluorescence

107

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“…The CV's of Glucometer Gx are higher than those of the other four instruments. Glucometer II, the predecessor of Glucometer Gx, displayed similar characteristics (10,11).…”

Section: Discussionmentioning

confidence: 95%

Laboratory Assessment of Five Glucose Meters Designed for Self-Monitoring of Blood Glucose Concentration

Devreese¹,

Leroux‐Roels²

1993

Clinical Chemistry and Laboratory Medicine

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Summary:We describe a laboratory assessment of five blood glucose meters. The instruments' analytical characteristics under optimum laboratory conditions and examination of potential sources of errors were intercompared. All glucometers produced precise results, and in all but one meter the CV values varied between 1.5% and 6%. CV's for reproducibility and within-day precision of Glucometer Gx were 10.5% and 7.3%. Sample volume, blood incubation time and colour stability of the strip may influence the results of blood glucose measurements with glucose meters. Underloading the sample strip had statistically significant effects on normal blood glucose values for all meters. One Touch II gave also significantly different results when the strip was overloaded. Incubation times shorter or longer than those recommended by the manufacturer influenced the results of all glucose meters. After colour development of the strip, changes were small for Haemo-Glukotest 20-800R strips and Glucotrix, whereas Accutrend glucose strips had to be read immediately following the prescribed incubation time. Comparison of the glucose meter results with those obtained by the hexokinase method showed good correlation coefficients for Reflolux S (r = 0.992), Accutrend (r = 0.988), One Touch II (r = 0.942), Glucometer Gx (r = 0.986) and Glucocard (r = 0.976). Error grid analysis showed that the results of all meters were clinically correct. Variations in haematocrit are known to be a source of errors when blood glucose is determined with a test strip. In the normoglycaemic range the results obtained with Accutrend and Glucocard were not influenced by even extreme haematocrit values. In the high glucose concentration range there was a decrease in blood glucose values with increasing haematocrit for all meters. This error was smaller with Accutrend and Glucocard than with the other meters.Although the new versions of the monitors are easier to use, their analytical performance is not superior to earlier models.

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“…One of the major challenges in the management of diabetes is the monitoring of glucose concentrations. Despite intensive efforts [1][2][3][4][5], no method is currently available for the continuous non-invasive monitoring of blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Tunable plasmonic glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids

Aslan

Lakowicz

Geddes

2004

Analytica Chimica Acta

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We describe a new approach for glucose determination with tunable glucose dynamic sensing ranges, dependent on the properties of new nanosensors, which are comprised of Con A-aggregated dextran-coated gold colloids.Dextran-coated 10 or 20 nm gold colloids can be aggregated with Con A in a controlled fashion, the change in absorbance at an arbitrary wavelength used to monitor the extent of aggregation, which can be optimized for sensing. The presence of any glucose competitively binds with Con A, dissociating the dextran-coated colloids, affording for the reverse gold plasmon change and hence the determination of glucose concentrations. For one of our sensor systems, a 500K dextran-20 nm gold sensor, crosslinked with 8.70 M Con A, a change in absorbance at 650 nm of 0.03 was observed, in response to as little as 3 mM glucose. In contrast, a 500K dextran-10 nm gold 18.7 M Con A aggregate sensor, produced a 0.05 and 0.1 change in absorbance, respectively, by the addition of 50 and 100 mM glucose.We have found that the glucose sensing ranges can be somewhat tuned by altering the properties, and therefore the extent of aggregation of the gold aggregate sensors. Reducing the gold colloid size and dextran molecular weight typically reduces the glucose sensing range (lower [glucose]) but also reduces the long-term stability of the gold aggregate sensor. Similarly the concentration of Con A used to aggregate the system also has an effect on long term sensor stability and glucose response.In this paper, we present our findings, which offer unique opportunities and perspectives for building tunable plasmonic type glucose sensors.

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An evaluation and comparison of Reflolux II and Glucometer II, two new portable reflectance meters for capillary blood glucose determination

Cited by 39 publications

References 10 publications

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring

Laboratory Assessment of Five Glucose Meters Designed for Self-Monitoring of Blood Glucose Concentration

Tunable plasmonic glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids

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