This work presents an investigation of the effects of tsunamis on bridge superstructures, with specific attention focused toward the differences between two-dimensional (2D) and threedimensional (3D) analyses. For the most part, available research on tsunami-bridge interaction is based on 2D analysis. While 2D analyses can provide estimates of drag force, uplift, and overturning moment per unit length, they do not account for critical 3D phenomena such as channelization effects due to local bathymetry, bridge skew and other non-uniform geometric aspects. Using a high-fidelity 3D computational fluid dynamics approach, validated against existing experimental data, this work analyzes the temporal and spatial dynamics of tsunami loading on a model bridge and shows how variation in the local geometry, specifically the skew angle of the bridge relative to the incoming wave, can affect the loading history on the structure.