An ethnopharmacological study on Verbascum species: From conventional wound healing use to scientific verification

Süntar, İpek; Tatlı, I. İrem; Akkol, Esra Küpeli; Keleş, Hikmet; Kahraman, Cigdem; Akdemir, Zeliha Ş.

doi:10.1016/j.jep.2010.08.004

Cited by 36 publications

(27 citation statements)

References 20 publications

(19 reference statements)

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“…The majority of the available drugs in developing countries are driven from medicinal plants; and in industrialized countries, plants make up the raw material for the synthesis of pure chemical derivatives (15).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Aqueous-Alcoholic Extracts and the Essential Oil of Verbascum thapsus L.

Ghasemi

Rezaei

Araghi

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:The increasing resistance of human pathogens to the available antimicrobials is a serious threat, resulting in the need for novel antibiotic resources such as plants. Some species of the genus Verbascum have been used by mankind since ancient times as an effective remedy for infectious diseases. Objectives: This study was designed to determine the antimicrobial efficacy of the aqueous-alcoholic extracts and the essential oil of Verbascum thapsus L. against different kinds of bacterial and fungal strains, viz. Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus fumigatus. Materials and Methods:The antimicrobial activities of the V. thapsus extracts were examined in the present study on the basis of disc diffusion and microdilution assays, and their potency was quantitatively assessed in terms of inhibition zone diameters and minimum inhibitory concentration (MIC) values. Results:The disk diffusion test showed that the methanol extract of V. thapsus had more growth inhibitory effects on E. coli and S. pyogenes than the aqueous and ethanol extracts. The methanol and aqueous extracts had no effects on S. aureus. The maximal inhibition zone for the microorganisms sensitive to the methanol extract was in the range of 7 -16.8 mm, and the MIC value was 31.25 μg/mL. For the ethanol extract, the maximal inhibition zone was 5.3 -11 mm and the MIC value was 62.5 -125 μg/mL. The essential oil of V. thapsus did not exhibit any antibacterial and antifungal activities. Conclusions:The findings of the present study revealed the V. thapsus extract possesses compounds with antibacterial properties that can be used as novel antimicrobial agents in the development of new drugs for the treatment of infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Aqueous-Alcoholic Extracts and the Essential Oil of Verbascum thapsus L.

Ghasemi

Rezaei

Araghi

et al. 2015

Jundishapur J Nat Pharm Prod

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“…The WH activity of 13 Verbascum species was assessed in vivo using two models (linear incision and circular excision); V. olympicum Boiss, V. stachydifolium Lam, and V. uschackense Lam had the highest activities on the both wound models and the methanolic extracts of V. latisepalum Boiss, V. mucronatum Lam, and V. pterocalycinum var. mutense showed promising pro‐WH potential . Although mechanisms of pro‐WH actions of the Verbascum species remain unknown, some active phytochemicals were determined in the case of V. mucronatum Lam …”

Section: Medicinal Plants Of the World Flora With Wh Activitymentioning

confidence: 99%

“…Remarkably, about one‐third of all traditional herbal medicines are intended for treatment of wounds or skin disorders, compared to only 1–3% of modern drugs . Of note, the beneficial effects of plant extracts on skin wound healing (WH) has also gained support from several experimental studies . Given that in the United States alone chronic wounds affect 6.5 million patients, and that that the number of chronic wounds is likely to grow worldwide due to the increase in age‐related conditions and pathologies such as diabetes, obesity, and cardiovascular diseases, any therapeutic intervention aimed at facilitating the WH processes should not be disregarded.…”

Section: Introductionmentioning

confidence: 99%

Effect of medicinal plants on wound healing

Budovsky

Yarmolinsky

Ben‐Shabat

2015

Wound Repair Regeneration

139

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Nowadays, owing to drastic changes in social conditions, people are increasingly becoming stressed. Consequently, the number of people who want to be healed is also increasing. In this study, we focused on the use of plants to reduce stress. We develop a pseudo-communication system with plants using 7 sensors (for temperature, humidity, CO 2 , and so on), a microphone, and a display. The system will have healing effects such as those of counselors or animal-assisted therapy. Then, a communication experiment is carried out to confi rm that the proposed system can reduce user's stress. As a result, from amylase activity, it is found that user stress is reduced when the user uses the system when stressed. Therefore, it is clear that the proposed communication system has some healing effect on stressed users.

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“…Verbascum flowers are boiled in milk and are applied externally for pruritic conditions affecting the urogenital organs. Several species are specifically used in Turkey and said to be mildly diuretic and to have a soothing and anti-inflammatory effect on the urinary tract, in addition to acting as a mild sedative [152-153]. Oil prepared from the flowers is used to soothe earache, and can be applied externally to treat eczema and other types of inflammatory skin conditions [154].…”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

174

110

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Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo.

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An ethnopharmacological study on Verbascum species: From conventional wound healing use to scientific verification

Cited by 36 publications

References 20 publications

Antimicrobial Activity of Aqueous-Alcoholic Extracts and the Essential Oil of Verbascum thapsus L.

Antimicrobial Activity of Aqueous-Alcoholic Extracts and the Essential Oil of Verbascum thapsus L.

Effect of medicinal plants on wound healing

Anti-Inflammatory Iridoids of Botanical Origin

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