An ethnobotanical study of medicinal plants administered for the treatment of hypertension

Baharvand-Ahmadi, Babak; Bahmani, Mahmoud; Tajeddini, Pegah; Rafieian-Kopaei, Mahmoud; Naghdi, Nasrollah

doi:10.15171/jrip.2016.26

Cited by 50 publications

(25 citation statements)

References 14 publications

(16 reference statements)

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“…127 In Sistan and Baluchestan province, nigella (Nigella sativa L.) is used to treat HTN. 128 Milk thistle (Silybum marianum L.), yarrow (Achillea tenuifolia), chicory (Cichorium intybus), barberry (Berberis vulgaris), shepherd's purse (Capsella bursa-pastoris), field horsetail (Equisetum arvense), Persian walnut (Juglans regia), and annual yellow sweetclover (Melilotus indicus) are used in Kazerun to treat HTN. 129 In the Arasbaran region, barberry, yarrow (Achillea millefolium L.), ecballium (Ecballium elaterium), common hawthorn (Crataegus monogyna), and English yew (Taxus baccata L.) are considered to have BP lowering potential.…”

Section: Medicinal Plants Used For the Treatment Of Htn In Iranmentioning

confidence: 99%

Medicinal Plants in the Treatment of Hypertension: A Review

et al. 2020

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Traditional medicine is a comprehensive term for ancient, culture-bound health care practices that existed before the use of science in health matters and has been used for centuries. Medicinal plants are used to treat patients with cardiovascular diseases, which may occur due to ailments of the heart and blood vessels and comprise heart attacks, cerebrovascular diseases, hypertension, and heart failure. Hypertension causes difficulty in the functioning of the heart and is involved in atherosclerosis, raising the risk of heart attack and stroke. Many drugs are available for managing these diseases, though common antihypertensive drugs are generally accompanied by many side effects. Medicinal herbs have several active substances with pharmacological and prophylactic properties that can be used in the treatment of hypertension. This review presents an overview of some medicinal plants that have been shown to have hypotensive or antihypertensive properties.

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Section: Medicinal Plants Used For the Treatment Of Htn In Iranmentioning

confidence: 99%

Medicinal Plants in the Treatment of Hypertension: A Review

et al. 2020

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“…These drugs act at specific target sites on the renin-angiotensin-aldosterone system (RAAS) and in other organs related to the regulation of blood pressure. Although they are commonly in use, they are known to have side effects in patients on longterm treatment posing a question of reliability (Ahmadi, Bahmani, Tajeddini, Kopaei, & Naghdi, 2016;Popovi, Mati, Bojovi, Stefanovi, & Vidakovi, 2016).…”

Section: Pharmaceuticals In Hypertension Therapymentioning

confidence: 99%

Relieving the tension in hypertension: Food–drug interactions and anti‐hypertensive mechanisms of food bioactive compounds

2020

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Hypertension occurs when there is a pressure exerted by blood on the vessels, thereby causing the systolic or diastolic blood pressure (DBP) to be consistently and abnormally elevated above the normal threshold. Tabassum and Ahmad (2011) defined hypertension as having a systolic blood pressure (SBP) of ≥140 mmHg and a DBP of ≥90 mmHg. Additionally, it is the most important risk factor attributed to coronary heart diseases such as stroke, congestive heart failure, atherosclerosis, infarction, peripheral vascular disease, and overall mortality. There are two main types of hypertension: the first is termed essential hypertension which develops with no evident cause and the second is termed secondary hypertension, which exists due to prior disease conditions such as kidney problem, endocrine disorders, or diabetes (Paxherbal, 2010). The organs that are usually linked to hypertension are the heart, the kidney, vascular

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“…In fact, Borago seed oil is rich in γ-linolenic acid. This plant, traditionally used for its antispasmodic ( 18 ), antipyretic ( 19 ), antihypertensive ( 20 ), aphrodisiac ( 19 ), and diuretic ( 21 ) properties, has been also considered useful in the treatment of asthma ( 18 ), bronchitis ( 19 ), cramps ( 19 ), diarrhea ( 22 ), palpitations ( 19 ), and kidney pain ( 23 , 24 ). As for Borago constituents, tannins, resins, ascorbic acid, niacin, riboflavin, thiamine, silicic acid, flavonoids, coumarins, and several polyphenolic (caffeic, rosmarinic, and chlorogenic acid) and pyrrolizidine alkaloid compounds have been detected ( 18 , 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study

et al. 2020

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Stress is a typical body's natural defense to a generic physical or psychic change. A specific linking mechanism between ulcer onset and psycho-physical stress prolonged exposure has been reported. We decided to investigate the possible effects of Borago officinalis L. (Borago) in preventing physical (stress)-induced gastric ulcers in a rat model. Eighty male Sprague-Dawley rats were randomly divided into 16 groups, pretreated with a control solution, omeprazole (20 mg/kg), Borago methanolic extract (25, 50, 100, 250, and 500 mg/kg), Borago organic extract (50, 100, 250, and 500 mg/kg), Borago aqueous extract (5, 10, 20, 30, and 40 mg/kg), and D(-)-2-Amino-5-phosphonovaleric acid (AP5) (25 mg/kg) and kept in stressful conditions such as water immersion and restraint-induced stress ulcers. The animals were sacrificed and their stomach scored for the severity and the number of gastric ulcers. Methanolic extract (500 mg/kg) significantly reduced both ulcer parameters ( *** p < 0.001 and ** p < 0.01, respectively). Aqueous and organic extract significantly decreased severity score at 5 and 10 mg/kg ( ** p < 0.01 and *** p < 0.001, respectively), and at 250 and 500 mg/kg ( *** p < 0.001), respectively, while gastric ulcers' resulted number significantly reduced only at 10 mg/kg ( * p < 0.05) and at 500 mg/kg ( ** p < 0.01), respectively. On the other hand, aqueous extract significantly increased the mucosal gastric content of cAMP ( * p < 0.05) and NR2A and NR2B subunits ( * p < 0.05 and ** p < 0.01, respectively) at 5 mg/kg. Organic extract showed also a significant cytotoxic effect at 500 and 1,000 mg/kg with a 3T3 cell viability reduction of 43.6% ( ** p < 0.01) and 92.1% ( *** p < 0.001), respectively. Borago aqueous extract at 10 mg/kg could be considered as a potential protective agent against stress-induced ulcers, and it is reasonable to possibly ascribe such protective activity to a modulation of the NR2A and NR2B subunit expression.

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An ethnobotanical study of medicinal plants administered for the treatment of hypertension

Cited by 50 publications

References 14 publications

Medicinal Plants in the Treatment of Hypertension: A Review

Medicinal Plants in the Treatment of Hypertension: A Review

Relieving the tension in hypertension: Food–drug interactions and anti‐hypertensive mechanisms of food bioactive compounds

Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study

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