An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa
Davide Di Fusco,
Maria Teresa Segreto,
Andrea Iannucci
et al.
Abstract:Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory molecules are not well understood. Adenosine deaminase acting on RNA 1 (ADAR1), an RNA-editing enzyme, plays a crucial role in inhibiting self or viral RNAs from activating auto-immune mediated responses, most notably within the type-I IFN production pathway. The aim … Show more
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