“…However, in plants, genes that encode class I or II PI3K are missing, and only the class III PI3K, which makes PtdIns(3)P from PtdIns, has been identified (Hong and Verma, 1994;Welters et al, 1994). The prototype for this type of enzyme, Vps34p, was first identified in Saccharomyces cerevisiae, in which it is required for the delivery of soluble proteins to the vacuole (Herman et al, 1992;Schu et al, 1993). Subsequently, a human homolog was identified, and Vps34p-related PI3Ks are now known to exist in a range of other eukaryotes, including Dictyostelium (Zhou et al, 1995), Drosophila (Linassier et al, 1997), and plants (Hong and Verma, 1994;Welters et al, 1994).…”