“…Prevalence of RBD in the general population is between 0.38 and 0.5%, but RBD has been found in 70% of patients with MSA, 40% of patients with DLB, and between 15% and 33% of patients with PD [ 69 – 71 ]. Another study even showed that 74% of the DLB population had RBD [ 72 , 73 ]. By using diffusion magnetic resonance imaging (MRI), PD patients with RBD showed microstructural white matter changes in the bilateral cingulum, inferior front occipital fasciculus, bilateral corticospinal tracts, and middle cerebellar peduncles.…”
Section: Clinical Implications Of Rbd and Its Relationship To Dlbmentioning
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.
“…Prevalence of RBD in the general population is between 0.38 and 0.5%, but RBD has been found in 70% of patients with MSA, 40% of patients with DLB, and between 15% and 33% of patients with PD [ 69 – 71 ]. Another study even showed that 74% of the DLB population had RBD [ 72 , 73 ]. By using diffusion magnetic resonance imaging (MRI), PD patients with RBD showed microstructural white matter changes in the bilateral cingulum, inferior front occipital fasciculus, bilateral corticospinal tracts, and middle cerebellar peduncles.…”
Section: Clinical Implications Of Rbd and Its Relationship To Dlbmentioning
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.
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