An equation to describe dose responses where there is stimulation of growth at low doses

Brain, P.; Cousens, Roger

doi:10.1111/j.1365-3180.1989.tb00845.x

Cited by 280 publications

(248 citation statements)

References 6 publications

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“…If the data fits the model within a confidence limit, usually of 95%, it is assumed that hormesis is present. There are some models that can be modified to better fit the hormetic response, including the quadratic function (93), Gompertz function (94,95) and logistic function (96). Deng et al (97) summarized some of these model-based approaches and developed a method to estimate the magnitude of the hormetic response.…”

Section: Studying Hormesismentioning

confidence: 99%

“…Deng et al (97) summarized some of these model-based approaches and developed a method to estimate the magnitude of the hormetic response. When testing for chemical hormesis the Brain and Cousens model (96), based on the logistic function, is the most commonly used. Further modifications of the Brain and Cousens model have been made by Van Ewijk and Hoekstra (98), and Schabenberger et al (23) in order to allow estimation of different parameters that are relevant for toxicology such as EC50, NOAEL and maximum stimulation dose (MSD).…”

Section: Studying Hormesismentioning

confidence: 99%

See 1 more Smart Citation

Hormesis: Biphasic Dose-Responses to Fungicides in Plant Pathogens and Their Potential Threat to Agriculture

Garzón¹,

Flores²

2013

Fungicides - Showcases of Integrated Plant Disease Management From Around the World

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Section: Studying Hormesismentioning

confidence: 99%

Section: Studying Hormesismentioning

confidence: 99%

Hormesis: Biphasic Dose-Responses to Fungicides in Plant Pathogens and Their Potential Threat to Agriculture

Garzón¹,

Flores²

2013

Fungicides - Showcases of Integrated Plant Disease Management From Around the World

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“…For the inhibition effect of aBSM/BSM on MDA-MB-231, a five-parametric Brain-Cousens hormesis model was used for fitting (61). and the abundance of sialyl groups on the cell surface, HeLa, MCF7, and MDA-MB-231 cells were treated with neuraminidase and subsequently exposed to riproximin in a cellular viability assay.…”

Section: Figure 2 Elisa Binding Analysismentioning

confidence: 99%

Evaluation of Riproximin Binding Properties Reveals a Novel Mechanism for Cellular Targeting

Bayer

Essig

Stanzel

et al. 2012

Journal of Biological Chemistry

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Background: Riproximin is a cytotoxic lectin from Ximenia americana showing tumor selectivity. Results: Riproximin selectively binds to two types of glycoconjugates present on glycoproteins, cross-linking them by its two binding sites. Conclusion:The biologic activity of riproximin is determined by specific and dynamic interactions with multivalent, cancerrelated glycan targets. Significance: The selectivity of riproximin for cancer cells relies on its unique targeting mechanism.

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“…Resistance in the dose-response curve experiment is confirmed if there is a statistical difference in response to the herbicide between the resistant biotype and the susceptible biotype, evidenced by non-linear regression models (Brain & Cousens, 1989).…”

Section: Methodsmentioning

confidence: 99%

Resistance of Raphanus raphanistrum to the herbicide metsulfuron-methyl

Costa

Rizzardi

2014

Planta daninha

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-The ALS-inhibiting herbicides, especially metsulfuron-methyl, are widely used for weed control, mainly wheat and barley in southern Brazil. Raphanus raphanistrum is a major weed of winter crops. However, in recent years, R. raphanistrum, after being treated with metsulfuron, has shown no symptoms of toxicity, possibly due to herbicide resistance. Aiming to evaluate the existence of R. raphanistrum biotypes resistant to metsulfuron, an experiment was conducted in a greenhouse, in a completely randomized design with four replications. The plots consisted of pots with six plants. The treatments consisted of the interaction of resistant R. raphanistrum (biotype R) and susceptible R. raphanistrum (biotypes S) with ten doses of the herbicide (0.0; 0.6; 1.2; 2.4; 4.8; 9.6; 19.2; 38.4; 76.8 and 153.6 g i.a. ha -1 ). The application of the test herbicides occurred when the crop was at the stage of 3 to 4 true leaves. The variables analyzed were control and dry matter accumulation. Statistical analysis of dose-response curves was performed by non linear regression. Biotype S was susceptible to the herbicide even at doses below the recommended. Biotype R was insensitive to the herbicide obtaining values of resistance factor (F) higher than 85. The dose-response curve confirmed the existence of R. raphanistrum biotypes with high level of resistance to metsulfuron-methyl.Keywords: acetolactate synthase, dose-response, weed, resistance factor. (0,0; 0,6; 1,2; 2,4; 4,8; 9,6; 19,2; 38,4; 76,8; e 153,6 g i.a. ha -1 Palavras-chave: acetolactato sintase, dose-resposta, planta daninha, fator de resistência. RESUMO -Os herbicidas inibidores de ALS, especialmente metsulfuron metílico, são amplamente utilizados para controle de plantas daninhas, principalmente em trigo e cevada, no sul do Brasil. Raphanus raphanistrum é planta daninha comum em culturas de inverno. No entanto, nos últimos anos, plantas de R. raphanistrum têm sobrevivido após o tratamento com o herbicida. Com o objetivo de avaliar a existência de biótipos de R. raphanistrum resistentes ao herbicida metsulfuron, foi conduzido experimento em casa de vegetação, em delineamento inteiramente casualizado com quatro repetições. As unidades experimentais consistiram de vasos contendo seis plantas cada. Os tratamentos constaram da interação de R. raphanistrum resistente (biótipo R) e suscetível (biótipo S) com dez doses crescentes do herbicida

show abstract

An equation to describe dose responses where there is stimulation of growth at low doses

Cited by 280 publications

References 6 publications

Hormesis: Biphasic Dose-Responses to Fungicides in Plant Pathogens and Their Potential Threat to Agriculture

Hormesis: Biphasic Dose-Responses to Fungicides in Plant Pathogens and Their Potential Threat to Agriculture

Evaluation of Riproximin Binding Properties Reveals a Novel Mechanism for Cellular Targeting

Resistance of Raphanus raphanistrum to the herbicide metsulfuron-methyl

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