An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring

Kunnel, Brince Paul; Demuru, Silvia

doi:10.1039/d2lc00183g

Cited by 21 publications

(21 citation statements)

References 64 publications

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“…71 The ISF is more similar in composition to blood than sweat, hence higher analyte concentrations for biosensing. 72,73 Aside from in situ ISF sensing, 16,74 recent works reported collecting the ISF, 19,75 for downstream analysis such as transcriptomics, 72 proteomics, 76 and metabolomics. 72 This is due to ISF sampling via MN avoiding patient discomfort as compared to conventional blood sampling via hypothermic needle/finger prick.…”

Section: Resultsmentioning

confidence: 99%

PEDOT coated microneedles towards electrochemically assisted skin sampling

et al. 2023

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Section: Resultsmentioning

confidence: 99%

PEDOT coated microneedles towards electrochemically assisted skin sampling

et al. 2023

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“…[ 84 ] Attaching a collection chamber at the end of the electrode may allow the collection and storage of a small volume of ISF. [ 85 ] Iontophoretic procedures are very limited by the molecule's charge due to its basic principle and the fact that skin itself has a negative net charge, making it selectively permeable for mostly cationic species. It works with small biomolecule extraction, but the instruments are bulky, and the interpretation of the results requires frequent calibration.…”

Section: Current Methods To Sample Interstitial and Other Tissue Fluidsmentioning

confidence: 99%

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Himawan

Vora

Permana

et al. 2022

Adv Healthcare Materials

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Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from the fluids surrounding the diseased tissues may give more important clinical value than measuring them at a systemic level. Despite all these facts, pushing tissue fluid-based diagnosis and monitoring forward to clinical settings faces one major problem: its accessibility. Most extracellular tissue fluid, such as interstitial fluid (ISF), is abundant but hard to collect, and the currently available technologies are invasive and expensive. This is where novel microneedle technology can help tackle this significant obstacle. The ability of microneedle technology to minimally invasively access tissue fluid-containing biomarkers will enable ISF and other tissue fluid utilization in the clinical diagnosis and monitoring of localized diseases. This review attempts to present the current pursuit of the application of microneedle systems as a diagnostic and monitoring platform, along with the recent progress of biomarker detection in diagnosing and monitoring localized external organ diseases. Then, the potential use of various microneedles in future clinical diagnostics and monitoring of localized diseases is discussed by presenting the currently studied cases.

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“…Microchannels parallel to the skin are connected to the sweat glands through vertical channels. [ 57 ] In the process of perspiration, sweat is concentrated in the vertical channels through the capillary force. After reaching a certain amount, the sweat flows through the microchannels under the action of the siphon effect and reaches the analysis area.…”

Section: Sweat Collection Methodsmentioning

confidence: 99%

Recent Advances toward Wearable Sweat Monitoring Systems

Shen

Xue

et al. 2022

Adv Materials Technologies

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Wearable biosensors are playing an increasingly important role in society. Compared with traditional wearable biosensors for detecting blood pressure, blood oxygen, or pulse conditions, which can only access information from the physical level, biosensors for testing body fluids can provide more details on health conditions through the analysis of biochemical criteria. Sweat secreted from glands distributed throughout the body contains abundant biochemical information and is an indicator of the physical conditions. Because of the noninvasive and safe sampling method, wearable sweat monitoring systems have the potential to realize long‐term and wearable detection. In this review, the current situation of wearable sweat monitoring systems is summarized from three critical parts: the sweat collection method, the sweat analysis method, and the energy supply. Finally, based on the existing drawbacks of wearable sweat monitoring systems in previous studies, the authors creatively propose droplet‐based detection, triboelectric nanogenerator‐based detection, and self‐powered systems as new directions for future research. The proposed approaches are expected to promote the commercialization process of wearable sweat monitoring systems.

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An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring

Abstract: Simultaneous access to the different biofluids enables an accurate analysis of multiple analytes, leading to a precision diagnosis and medication. Additionally, establishing a relationship between various markers at different biofluids...

Cited by 21 publications

References 64 publications

PEDOT coated microneedles towards electrochemically assisted skin sampling

PEDOT coated microneedles towards electrochemically assisted skin sampling

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Recent Advances toward Wearable Sweat Monitoring Systems

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