An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Xiao, Shuifang; Li, Jinrang; Zheng, Hongliang; Yan, Yan; Li, Xiangping; Zhang, Lihong; Lv, Quiping; Zhang, Junbo; Zeng, Lin; Gao, Xia; Xiong, Chen; Yang, Hui; Zhao, Chen; Zhang, Jian; Lu, Honghua; Luo, Xianyang; Wang, Guangke; Yi, Hongliang; Ye, Jin; Lin, Zhenqun; Tian, Linli; Zhang, Jingjing; Chen, Ting; Yu, Aimin; Liu, Zhaohui; Ren, Xiaoyong; Yang, Xinming; Zhang, Siyi; Cui, Xiaobo; Li, Gelin; Wan, Guanghua; Chang, Lin; Chen, Hui; Deng, Anchun; Tang, Xiabing; Tao, Zhenfeng; Shi, Li; Zhou, Jing; Qin, Gang; Zhuang, Pinghui; Hui, Hongxiang; Yang, Jianming; Zhou, Guojin; Li, Huijun; Wu, Wei; Li, Julan; Li, Shuhua; Lou, Guangming; Fang, Hongyan; Ma, Jiangang; Shan, Chunguang; Zhou, Xuejun; Tang, Liang; Zhou, Fang Liz; Fan, Yunping; Zhang, Yanping; Li, Yujie; Li, Meisheng; Dou, Chunqiang; Chen, Zhiling; Lei, Gang; Li, Jingbo; Gao, Zhiguang; Huang, Yuyu; Ma, Xinchun; Liu, Zhijun; Liang, Gengtian; He, Jie; Zhao, Hua; Song, Bailong; Chen, Meijun; Yang, Xiangli; Ma, Zuopeng; Ren, Jing

doi:10.1007/s00405-020-06045-0

Cited by 25 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 6 Chinese researchers found that the incidence of LPR among otolaryngology and head and neck surgery outpatients was 10.15% in China. 7 However, the true incidence of LPR in the general population is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Multitime point pepsin testing can double the rate of the diagnosis of laryngopharyngeal reflux

Zhang

et al. 2021

Laryngoscope Investig Oto

Self Cite

View full text Add to dashboard Cite

Objective: To study the value of multitime point salivary pepsin testing (MTPSPT) for the diagnosis of laryngopharyngeal reflux (LPR).Study Design: Prospective noncontrolled.Methods: For patients who met the enrollment criteria, the reflux symptom index (RSI) and reflux finding score (RFS) were calculated and salivary pepsin testing was performed. The pepsin test was performed every hour from 7:00 a.m. to 6:00 p.m. by collecting fresh saliva samples. A single positive test result was needed for the diagnosis of LPR. The consistency in the diagnosis of LPR between the two methods was compared with the weighted Cohen's kappa statistic.Results: A total of 204 patients were included. The kappa value between the two methods was 0.566 (p = .00). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MTPSPT were 76.43%, 85.94%, 92.24%, and 62.5%, respectively. We also compared a single pepsin measure at 7 a.m. with the screening results based on the RSI and RFS, and found a much lower kappa agreement value (0.223, p = .00). The sensitivity, specificity, PPV, NPV, and false-negative rate of pepsin testing at 7 a.m. (fasting) were 37.86%, 92.18%, 91.38%, 40.41%, and 58.57%, respectively. Conclusion:The use of the result of a single salivary pepsin test in the morning yields a relatively higher rate of missed diagnosis of LPR, and multitime point testing through a day increased the accuracy and sensitivity of detection of LPR twofold compared to a single morning fasting sample.

show abstract

Section: Introductionmentioning

confidence: 99%

Multitime point pepsin testing can double the rate of the diagnosis of laryngopharyngeal reflux

Zhang

et al. 2021

Laryngoscope Investig Oto

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent multi-center epidemiological survey in China shows that the incidence of LPRD among outpatients in otolaryngology in China was about 10%, and there are regional, gender and age differences ( 8 ). LPRD can cause adult asthma, idiopathic pulmonary fibrosis and sinusitis, otitis media, tumors, and other otorhinolaryngology diseases.…”

Section: Discussionmentioning

confidence: 99%

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Liu

Xiao

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

ObjectiveTo observe the correlation between laryngopharyngeal reflux disease (LPRD) and patients' sleep status, and to explore the related factors of LPRD.MethodsFour hundred and sixteen patients who visited the otorhinolaryngology clinic in our hospital from June 2019 to June 2021 were selected as the research subjects. According to the scale of reflux symptom index, the subjects were divided into a patients group (120 patients) with an the reflux symptom index (RSI) > 13 and a control group (296 patients) with an RSI ≤ 13 according to the RSI scale score. General patient information was collected. The sleep state and emotional state of patients in the two groups were evaluated, and the related influencing factors for LPRD were also evaluated. The correlation between sleep state and depression in LPRD patients was analyzed.ResultsFour hundred and sixteen patients were divided into patients group and control group according to RSI score, the ratio of the two groups was 1:2.47. In the patients group, the common symptoms of RSI score and the top three of the total score were as follows: Foreign body sensation in throat in 112 patients, 438 points; Keep voice clear in 108 patients, 381 points; Excessive phlegm or nasal discharge reflux in 101 patients, 348 points. The PSQI and HADS scores in the patients group were higher than those in the control group (t = 19.990, 13.007, 14.690, P all <0.001). Logistic regression analysis showed that high-fat diet and high PSQI score were the risk factors for the development of LPRD (P = 0.012, P = 0.007). According to the PSQI score, the patients in the patients group were divided into 35 patients with abnormal PSQI score, 85 patients with normal PSQI score, and the HADS scores of those with abnormal PSQI score were all lower than those with normal PSQI score (P > 0.05). The PSQI score of the patients in the patients group was positively correlated with the HADS score (r = 0.714, P = 0.013).ConclusionSleep disorder may lead to the occurrence or aggravation of anxiety and depression in patients with LPRD, and it is an independent risk factor for the development of LPRD. Clinical attention to the treatment of sleep disorders in patients with LPRD may be conducive to improving the efficacy of LPRD.

show abstract

“…6 However, the frequency of a previous diagnosis of LPRD was found to be extremely low among those with positive symptoms, only 14.09%. 6 Besides the non-specific symptoms and clinical signs which are easily to be confused with other laryngopharyngeal disorders. 7 We hypothesised that an insufficient knowledge about this disease among the physicians might contribute a lot to such a low diagnosis rate.…”

Section: Introductionmentioning

confidence: 91%

“…The studies conducted in the USA, the UK and Greece reported that the prevalence of this disease could reach 10%, 34.4% and 18.8%, respectively 3–5. A national multicentre epidemiological survey conducted in China found that the prevalence of LPRD was as high as 10.15% at the otolaryngology-head and neck surgery clinics 6. However, the frequency of a previous diagnosis of LPRD was found to be extremely low among those with positive symptoms, only 14.09% 6.…”

Section: Introductionmentioning

confidence: 99%

“…A national multicentre epidemiological survey conducted in China found that the prevalence of LPRD was as high as 10.15% at the otolaryngology-head and neck surgery clinics 6. However, the frequency of a previous diagnosis of LPRD was found to be extremely low among those with positive symptoms, only 14.09% 6. Besides the non-specific symptoms and clinical signs which are easily to be confused with other laryngopharyngeal disorders 7.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey

Xiao

Zheng

et al. 2022

BMJ Open

Self Cite

View full text Add to dashboard Cite

ObjectivesThis study aimed to investigate the status of the current knowledge about laryngopharyngeal reflux disease (LPRD) among Chinese otolaryngologists.DesignMulti-centre cross-sectional survey.Setting220 medical centres in different regions of China.ParticipantsA total of 2254 otolaryngologists from 220 medical centres in China who were successfully on-site surveyed between November 2019 and December 2020.Main outcome measuresAwareness about LPRD included knowledge about risk factors, symptoms, laryngoscope signs, related diseases, current diagnostic methods and treatments.ResultsThe percentage of participants who had heard of LPRD was 96.4%, with academic conferences as the most common source of information (73.3%). The most commonly known risk factor, symptom, laryngoscope sign, related disease, diagnostic method and treatment were alcohol consumption (44.0%), pharyngeal foreign body sensation (66.9%), hyperaemia (52.4%), pharyngolaryngitis (54.8%), pH monitoring (47.6%) and medication (82.1%), respectively. Only 28.3% of all participants knew that 24 h pH or multichannel intraluminal impedance pH monitoring was the most accurate diagnostic test. As many as 73.1% of all participants knew that proton pump inhibitors were the first-line treatment drugs. An analysis of the overall status of awareness using a scoring system suggested that otolaryngologists were better aware owing to more access, working at 3A hospitals, and postgraduate or above educational background (all p<0.05).ConclusionAlthough the majority of Chinese otolaryngologists had heard of LPRD, their overall awareness about the disease was not encouraging. More efforts are needed to increase the knowledge about LPRD among this group of physicians.Trial registration numberChiCTR1900025581

show abstract

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Cited by 25 publications

References 33 publications

Multitime point pepsin testing can double the rate of the diagnosis of laryngopharyngeal reflux

Multitime point pepsin testing can double the rate of the diagnosis of laryngopharyngeal reflux

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey

Contact Info

Product

Resources

About