An epidemiological study of oesophageal atresia

Aspects of esophageal atresia in a population-based setting: incidence, mortality, and cancer risk

“…The incidence of 3.16 cases per 10,000 live births in the present study is well in line with findings in previous population-based studies, but is based on a larger sample, and might therefore represent a more robust estimate. The reported frequency of associated anomalies has varied between 43 and 61% in previous research [1,2,16]. The present study confirms this high prevalence of associated anomalies in patients with EA.…”

“…That study, however, was not populationbased, but was based on several registers of congenital malformation with different ascertainment and coverage. In one population-based study the EA incidence was reported to be 3.4 per 10,000 births, based on 227 cases in the southwest of England [1], while another population-based study, with 292 cases registered in the California Birth Defects Monitoring Program, showed an incidence of 2.82 per 10,000 births [16]. The incidence of 3.16 cases per 10,000 live births in the present study is well in line with findings in previous population-based studies, but is based on a larger sample, and might therefore represent a more robust estimate.…”

“…Incidence. The incidence of EA has been reported to be around 3 per 10,000 births, without any major changes with time [1,2]. According to the available literature, approximately 50% of all infants with EA have at least one associated anomaly, most often of cardiac origin.…”

Oesophageal atresia in the South West of England.

“…Necropsy had been performed in 153 of the 172 cases (89%) who had died or were stillborn. The incidence of oesophageal atresia was estimated to be 0.34 per 1000 births (David and O'Callaghan, 1974a).…”

Genetic and environmental factors in the etiology of esophageal atresia and/or tracheoesophageal fistula: An overview of the current concepts

“…Various environmental factors have been suggested to be a risk for the development of tracheoesophageal anomalies, including maternal exposure to methimazole, statins, alcohol, smoking or exogenous sex hormones, maternal phenylketonuria, infectious disease, or work in agriculture or horticulture (David and O'Callaghan, 1974;Harlap et al, 1975;Goujard and Rumeau-Rouquette, 1977;Bracken et al, 1978;Rothman and Louik, 1978;Wilson and Brent, 1981;Czeizel and Ludanyi, 1985;Szendrey et al, 1985;Wing et al, 1994;Clementi et al, 1999;Di Gianantonio et al, 2001;Felix et al, 2007a;WongGibbons et al, 2008). However, these risk factors have not been confirmed in other studies.…”