An Epidemiological Study of Legg-Perthes Disease

Low plasma levels of Insulin-like Growth Factor I in Perthes' disease A controlled study of 59 consecutive children

“…The principal agent in this group is somatomedin CDGF I (Phillips and Vassilopoulou-Sellin 1980), while the role of IGF I1 in the control of postnatal growth has not been fully clarified. GH-plasma levels seem to be normal in Perthes' disease (Fisher 1972, Tanaka et al 1984, but contradictory results were reported on the IGFs (Tanaka et al 1984, Burwell et al 1986, Rayner et al 1986, Kitsugi et al 1989.…”

“…Children with Perthes' disease have been shown to suffer from a general retardation of bone maturation (Fisher 1972, Harrison et al 1976, Kristmundsdottir et al 1987, raising the question of a hormonal disorder. The postnatal skeletal development is dependent on pituitary growth hormone (GH), the effects of which are mediated in part by the somatomedins or insulinlike growth-factors (Schoenle et al 1982, Nilsson et al 1986, Schlechter et al 1986, Trippel et al 1989).…”

A Twin Study of Perthes Disease

“…[22][23][24][25] However, these cases are likely to have been published because of the interesting observation of sibling concordance and so the literature is likely to reflect a selection bias. Studies that have reported high family concurrences often did not distinguish between LCPD and the many skeletal dysplasias that affect the hip joint, eg, multiple epiphyseal dysplasia.…”

Altered Postnatal Expression of Insulin-Like Growth Factor-I (IGF-I) and Type X Collagen Preceding the Perthes' Disease–Like Lesion of a Rat Model

“…(6) It also has been observed that children with arrested linear growth, which may be due to a disturbance of the endochondral ossification, are especially susceptible to Perthes' disease. (27,28) Although plasma GH levels among patients with Perthes' disease reportedly are normal, (27) several studies have reported abnormal levels of IGF-I. (14,15) Children with the disease are more prone to the problems of stature and growth, particularly in distal segments of the limbs.…”