An Epidemiological Study of Laboratory Confirmed COVID-19 Cases Admitted in Dhaka Medical College Hospital

Hossain, Md. Murad; Mark, Sayeef Hossain Khan; Kabir, Akm Humayon; Das, Partha Pratim; Islam, Khairul; Das, Aparna

doi:10.3329/jom.v21i2.50208

Cited by 6 publications

(14 citation statements)

References 19 publications

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“…22.44% of the mild cases was suffering from diabetes; several studies showed the similar result. 17,19 HTN (16.92%) was the 2nd most common comorbidities after DM which was consistent with several studies. 17,23 Only 1.9% patients were suffering from CKD that corresponds with other studies.…”

Section: Discussionsupporting

confidence: 89%

“…Similar findings were reported in other studies in Bangladesh where most of the patients were male (82.67%) and some previous studies showed male were more like 77% and 64%. 6,13,[16][17] It was suggested that ACE2 is the target receptor for COVID-19 that is greatly stated in males than in females which is present. 18,19 Presence of X chromosome and sex hormones may play a role for the less chance of getting infected with the virus in female.…”

Section: Discussionmentioning

confidence: 99%

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Overview of 254 mild cases of COVID-19 in Bangladeshi cohort: a cross-sectional observation

Zahan¹,

Nasir²,

Perveen³

et al. 2021

Int J Adv Med

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Background: The first recognition of a cluster of COVID-19 patients in China in late 2019, has become a major concern due to its greater transmissibility and vulnerability of the patient to turn to fever, cough, breathlessness, pneumonia then eventually severe acute respiratory distress syndrome requiring intensive care unit (ICU) support. But most of the affected patients get cured following mild symptoms and very only a few of them get hospitalized. The objective of the study was to observe the demographic characteristics, clinical symptoms, comorbidities, and biomarkers (hematological, inflammatory, hepatic, renal, and metabolic) of mild cases of COVID-19 infected patients admitted to the hospital during the peak four months of the pandemic.Methods: Age, sex, symptoms, comorbidities, and biomarkers (Hb%, WBC, lymphocyte, neutrophil, platelet count, HCT(hematocrit), NLR(neutrophil-lymphocyte ratio, d-NLR derived neutrophil-lymphocyte ratio, PLR(platelet-lymphocyte-ratio), d-Dimer, ferritin, CRP(C-reactive protein), PT(prothrombin time), INR(international normalized ratio), SGPT, S.creatinine, HbA1C of all rt-PCR positive mild cases were recorded in this retrospective observational study in a tertiary care hospital dedicated to COVID-19 at Dhaka, Bangladesh was done from 15th May to 9th September, 2020. Age, sex, symptoms, and comorbidities were compared by chi-square test and biomarkers were compared by one-way ANOVA. Results: Out of 254 cases 44 were female and 210 were male with a ratio of 1:4.77. Average age was 39.04. Largest population belongs to the 30-39 years of age range. Among the symptoms, anorexia (18.5%), fever (17.71%), and anosmia (16.9%) were most prevalent symptoms among the mild cases. However, diabetes mellitus (DM) and hypertension (HTN) were predominant comorbidities. Mostly all the biomarkers were significant among groups (Hb%, Total WBC, neutrophil count, platelet count, HCT, NLR, d-NLR, d-Dimer, ferritin, CRP, PT, SGPT, creatinine, HbA1C except lymphocyte count, PLR, and INR. The severity of disease progression depends on the co-morbidity and hyper-responsiveness inflammatory or immunological biomarkers to predict.Conclusions: In mild cases of COVID-19 male predominance was more and the most affected group was 30-39 years. They suffered more from anorexia and fever and DM and HTN were common comorbidities. Mostly all the biomarkers were significant. Moreover, further large-scale studies are needed to evaluate the number of mild cases and their prognostic features to develop and modify the treatment strategy and public health awareness time to time.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Overview of 254 mild cases of COVID-19 in Bangladeshi cohort: a cross-sectional observation

Zahan¹,

Nasir²,

Perveen³

et al. 2021

Int J Adv Med

View full text Add to dashboard Cite

show abstract

“…Data supports this concept that several thousand COVID-19 patients died in Europe and the USA, compared to Asian and African countries [17]. In a study in Bangladesh, the researcher found that patients who were dying due to COVID-19 had a significantly higher mean age than the alive group [16]. In the present study, the notable observation was that the highest percentage of patients were in the 60-69 years of age range among both survivors and the non-survivor (35.89%, 33.33%).…”

Section: Discussionmentioning

confidence: 83%

“…In another study published about ICU admitted patients in Bangladesh observed 77.5% of patients were male [5] and death among males was more common than females [14]. In another observation, the severe group contains more than double (29) male patients than female (12) in ICU [16]. We observed a greater percentage of males in survivors (42.42%) and non-survivors (30.3%) than the females (18.18%, 09.09%) in ICU.…”

Section: Discussionmentioning

confidence: 99%

“…In another study by Rawshan et al also reported shortness of breath as the commonest (86.42%) symptom among 81 critical COVID-19 patients in ICU [19]. But a few studies have reported a lower number of patients with shortness of breath in ICU as 24% and 46% respectively [16][17][18]. The management of 'shortness of breath' as respiratory distress or ARDS is the main strategy in the treatment of COVID-19 patients in ICU.…”

Section: Discussionmentioning

confidence: 99%

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Outcome of Instrumental Oxygen Therapy in COVID-19: Survivors Versus Non-survivors in Bangladeshi Cohort

Nasir¹,

Perveen²,

Ahmad³

et al. 2021

AJIM

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Background and objectives: Mortality of critically ill COVID-19 patients in ICU are high around the globe.There are variable reports on the outcome of invasive and non-invasive ventilation, change of oxygen saturation, and clinical characteristics in different countries and hospital set-ups. This study aimed to observe the demographic and clinical characteristics of critical COVID-19 cases, the trend of SpO 2 in 10-days, and the mortality outcome of oxygen therapy in a tertiary level hospital in Bangladesh. Methods: In this retrospective study, data obtained from 99 patients admitted in ICU with COVID-19 was confirmed by RT-PCR of the nasopharyngeal swab. The 720-bed Holy Family Red Crescent Medical College Hospital (HFRCMCH), Dhaka, Bangladesh with a 9-bed ICU facility designated as "COVID-dedicated" from May17 to September 9, 2020. Ninety-nine patients were selected for the study, divided into two groups. 39 of them were non-survivors, whereas 60 included in the survivors group. Demographic data, correlation with age groups, clinical symptoms, instrumental oxygen therapy, and mortality were collected from hospital records. Appropriate statistical analysis was done using SPSS version 26.0. Results: Out of 99 patients admitted in ICU with COVID-19, 72 were male and 27 were female. The mean age of the patients was 61.08 years. Most of the ICU patients were in the 60-69 years of age group and the highest mortality rates (35.89%) were observed in this age range. The presenting symptoms of the patients were shortness of breath (85.85%) was the most common symptom followed by fever (66.66%), cough (32.32%), lethargy (12.12%), and others (7.77%). The mean SpO 2 of their 10-days ICU stay was also variable between the two groups. A gradual increase of mean SpO 2 was observed in the survivors' group. Whereas, the mean SpO 2 level of non-survivor had ups and downs from 92% to 83% on day-10, along with the lowest level of mean SpO 2 (77%) was on the 7 th day. Conclusions: With the constrain of the healthcare support system and limited ICU facilities in a low-middle income country like Bangladesh, the mortality outcome and instrumental oxygen therapy to fight the ARDS caused by COVID-19 is far challenging. The present study clearly showed the highest mortality in patients who required mechanical ventilation, whereas, almost 75% of patients survived with high flow nasal cannula (HFNC). Therefore, the experience advocates the necessity of HFNC at the earliest possible time to avoid invasive ventilation in COVID-19 patients admitted in ICU.

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Paradox of Predictors in Critically ill COVID-19 Patients: Outcome of a COVID-dedicated Intensive Care Unit

Nasir¹,

Perveen²,

Nazneen

et al. 2021

Preprint

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Background: The study aimed to analyze the demographic, comorbidities, biomarkers, pharmacotherapy, and ICU-stay with the mortality outcome of COVID-19 patients admitted in the intensive care unit of a tertiary care hospital in a low-middle income country, Bangladesh. Methods: The retrospective cohort study was done in Holy Family Red Crescent Medical College Hospital from May to September 2020. All 112 patients who were admitted to ICU as COVID-19 cases (confirmed by RT-PCR of the nasopharyngeal swab) were included in the study. Demographic data, laboratory reports of predictive biomarkers, treatment schedule, and duration of ICU-stay of 99 patients were available and obtained from hospital records (non-electronic) and treatment sheets, and compared between the survived and deceased patients. Results: Out of 99 patients admitted in ICU with COVID-19, 72 were male and 27 were female. The mean age was 61.08 years. Most of the ICU patients were in the 60 - 69 years of age group and the highest mortality rates (35.89%) were observed in this age range. Diabetes mellitus and hypertension were the predominant comorbidities in the deceased group of patients. A significant difference was observed in neutrophil count, creatinine and, NLR, d-NLR levels that raised in deceased patients. There was no significant difference as a survival outcome of antiviral drugs remdesivir or favipiravir, while the use of cephalosporin was found much higher in the survived group than the deceased group (46.66% vs 20.51%) in ICU. Conclusions: Susceptibility to developing critical illness due to COVID-19 was found more in comorbid males aged more than 60 years. There were wide variations of the biomarkers in critical COVID-19 patients in a different population, which put the healthcare workers into far more challenge to minimize the mortality in ICU in Bangladesh and around the globe during the peak of the pandemic.

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An Epidemiological Study of Laboratory Confirmed COVID-19 Cases Admitted in Dhaka Medical College Hospital

Cited by 6 publications

References 19 publications

Overview of 254 mild cases of COVID-19 in Bangladeshi cohort: a cross-sectional observation

Overview of 254 mild cases of COVID-19 in Bangladeshi cohort: a cross-sectional observation

Outcome of Instrumental Oxygen Therapy in COVID-19: Survivors Versus Non-survivors in Bangladeshi Cohort

Paradox of Predictors in Critically ill COVID-19 Patients: Outcome of a COVID-dedicated Intensive Care Unit

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