An epidemiological study of collagenous colitis in southern Sweden from 2001-2010

Abstract

The observed incidence of CC is comparable with previous reports from northern Europe and America. The incidence is stable but the female: male ratio seems to be decreasing.

Are collagenous and lymphocytic colitis different aspects of the same disease?

“…Several differences have been observed between the two subtypes of MC; the female: maleratio has previously been higher in CC although the difference seems to decrease in recent studies [34]. CC is also regarded as a more inflammatory active disease with longer disease duration [21,35,36], even though a recent review indicates that the difference in disease activity might not be as pronounced as previously anticipated [28].…”

New insights and challenges in microscopic colitis

“…Population studies have shown an increasing incidence of MC over recent decades, with a mean incidence rate of 1.1-7.0/100,000 inhabitants for CC and an incidence rate of 3.1-5.5/100,000 inhabitants for LC [Fernandez-Banares et al 1999;Olesen et al 2004b;Pardi et al 2007;Vigren et al 2012;Thörn et al 2013]. The increased incidence has stabilized over the past years, and the incidence is associated with female gender and increasing age [Gentile et al 2014].…”

“…This north-south gradient has led to speculations that vitamin D is involved in the pathogenesis, but this has not been confirmed . The female-tomale ratio ranges from 2.8:1 to 7.5:1 for CC and from 2.1:1 to 2.7:1 for LC [Fernandez-Banares et al 1999;Olesen et al 2004b;Vigren et al 2012], whereas in a later review, the ratio was 3.0-9.0:1 for CC and 6.0:1 to no difference in LC [Pardi and Kelly, 2011]. The average age at diagnosis is approximately 65 years [Münch et al 2012].…”

“…Endocrine factors have been discussed since most studies report a female predominance of MC [Fernandez-Banares et al 1999;Olesen et al 2004b;Vigren et al 2012]. The intestinal epithelium provides a protective barrier for the internal milieu against luminal factors, which is dependent on intercellular, epithelial tight junctions [Turner, 2006].…”

Evolution of ideas on microscopic colitis

“…Эпиде-миологические данные, полученные в последние 10 лет, свиде-тельствуют о неуклонном росте распространенности и заболевае-мости МК [12,13]. В настоящее время распространенность МК составляет 103 случая (42 -КК, 69 -ЛК) на 100 000 населения, что сопоставимо с другими воспалительными заболеваниями ки-шечника, такими как язвенный колит (ЯК) и болезнь Крона (БК) [14].…”