An Epidemiological Study of 198 Cases of Primary Cicatricial Alopecia in Iran

Mokhtari, Fatemeh; Fatemi-Naeini, Farahnaz; Saber, Mina; Basiri, Akram; Matin, Marzieh

doi:10.9734/bjmmr/2017/27476

Cited by 3 publications

(1 citation statement)

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“…The most common type of lymphocytic lesions was discoid lupus erythematosus (25.8% of all patients). This higher rate of discoid lupus erythematosus in our study was similar to previous results reported by Naeini et al 2017, which presented a rate of 22.3% of affected patients and mostly were middle-age females [20].…”

Section: Discussionsupporting

confidence: 92%

Primary Cicatricial Alopecia among Lybian patients: A Clinicopathological and Epidemiological study

Musbah¹

2020

Iberoam J Med

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Introduction: Cicatricial alopecias are a group of disorders characterized by hair follicle destruction with the consequence of permanent hair loss. The current study was conducted to evaluate the epidemiological and clinicopathological characteristics of cicatricial alopecia in Libyan community. Methods: Thirty-one patients with confirmed diagnosis of cicatricial alopecia by biopsy and tricoscopy during Jan 2018 to Dec 2019 were included in this study. Data were collected by filling a pre-designed questionnaire by all included patients. Descriptive statistics were used for analyzing the results. Chi-squared test was performed to test the relationship between different variables using SPSS 22. Results: Out of 31 cases, 16.1% of patients suffered from lichen planopilaris (LPP), 25.8% discoid lupus erythematosus (DLE), 6% Folliculitis decalvans, 6.45% pseudopelade of brocq, and 16.12% Frontal fibrosing alopecia. Conclusions: Cicatricial alopecia was found to affect mainly middle-aged individuals, particularly females. Early diagnosis and treatment can decrease the burden of this concern.

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Section: Discussionsupporting

confidence: 92%

Primary Cicatricial Alopecia among Lybian patients: A Clinicopathological and Epidemiological study

Musbah¹

2020

Iberoam J Med

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Cyclosporine or methotrexate, which one is more promising in the treatment of lichen planopilaris?; A comparative clinical trial

Naeini

Mohaghegh

Jelvan

et al. 2020

International Immunopharmacology

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Clinical Effectiveness of Two Old Immunosuppressant Drugs, Methotrexate and Azathioprine, in the Treatment of Lichen Planopilaris: A Randomized Clinical Trial

Saber,

Hajheidari,

Fatemi Naeini

et al. 2024

Dermatologic Therapy

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Background. Lichen planopilaris is the leading cause of cicatricial alopecia, and its management is challenging for dermatologists. It is a cell‐mediated autoimmune disorder in which activated T‐lymphocytes attack hair follicles. Aim. To compare the efficacy and safety of methotrexate versus azathioprine, two medications that affect lymphocyte function, in treating LPP. Methods. 32 LPP patients were randomly assigned to receive either 15 mg/week methotrexate or 2 mg/kg azathioprine for six months. Treatment efficacy was evaluated using the Lichen Planopilaris Activity Index (LPPAI), trichoscopy, and photography after 2, 4, and 6 months of treatment. Results. Both methotrexate and azathioprine groups showed significant improvements in LPPAI (P < 0.001) and perifollicular scaling on trichoscopy (P < 0.01). However, the two groups had no significant difference during the study. The azathioprine group significantly improved perifollicular erythema on trichoscopy (P = 0.002), but this was not significantly different from the methotrexate group (P = 0.69). Photographic assessment showed that more than 75% of patients in both groups improved without significant differences between the two groups. Conclusion. Methotrexate and azathioprine are two antilymphocyte medications which are both equally effective and well‐tolerated for managing LPP. This trial is registered with IRCT20191006045005N2.

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An Epidemiological Study of 198 Cases of Primary Cicatricial Alopecia in Iran

Cited by 3 publications

References 0 publications

Primary Cicatricial Alopecia among Lybian patients: A Clinicopathological and Epidemiological study

Primary Cicatricial Alopecia among Lybian patients: A Clinicopathological and Epidemiological study

Cyclosporine or methotrexate, which one is more promising in the treatment of lichen planopilaris?; A comparative clinical trial

Clinical Effectiveness of Two Old Immunosuppressant Drugs, Methotrexate and Azathioprine, in the Treatment of Lichen Planopilaris: A Randomized Clinical Trial

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