An epidemiological investigation of cancer of the endometrium

Abstract

One hundred‐twelve endometrial cancer patients and 200 comparison patients were interviewed in New York hospitals. Additionally, the hospital records of more than 900 patients with endometrial cancer were reviewed. The most important factor found related to cancer of the endometrium is obesity. Tallness, in addition to obesity, enhances the risk of endometrial cancer distinctly. Other differences between the cancer patients and the comparison subjects, including late menopause, heavy menstrual bleeding and premenstrual breast swelling, suggest that the etiological basis for endometrial cancer may be increased retention of certain endogenous hormones. The most practical preventive measure for endometrial cancer appears to be an effective reduction in weight although the epidemiological proof of the consequences remains to be given.

Endometrial cancer following treatment for breast cancer: A case-control study in Denmark

“…In the absence of a previous diagnosis of breast cancer the most consistently reported risk factors for endometrial cancer are nulliparity, late age at menopause, obesity, and oestrogens for menopausal symptoms (Elwood et al, 1977;Ewertz, 1981;Kelsey et al, 1982;La Vecchia et al, 1982;MacMahon, 1974;Salmi, 1979;Wynder et al, 1966). Our results closely agree with those studies.…”

The epidemiology of endometrial cancer in young women

“…This is consistent with the results of studies of older mainly postmenopausal women (Damon, 1960;Wynder et al, 1966;Elwood et al, 1977;Kelsey et al, 1982;La Vecchia et al, 1982). Incomplete pregnancies also appear to be protective.…”

“…It is well known that obesity is a major risk factor for endometrial cancer in post-menopausal women (Damon, 1960;Wynder et al, 1966;Elwood et al, 1977;Kelsey et al, 1982;La Vecchia et al, 1982), and case reports have suggested that young endometrial cancer cases tend to be very obese (Sommers et al, 1949;Dockerty et al, 1951;Peterson, 1968). In our population 50% (55/110) of the cases weighed 2150lbs, and the associated attributable risk percent (ARP) is 38%, i.e.…”

Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target

“…23 SIRT1 was reported to be involved in the longevity induced by caloric restriction, 10 and its function in DNA repair and control of the cell cycle 24 was found to be similar to that of a tumor suppressor gene. Therefore, we first hypothesized that SIRT1 may be downregulated in the normal or cancerous tissues of women with a high BMI.…”