An Epidemiologic Study on the Correlation Between Oral Helicobacter pylori and Gastric H. pylori

Abstract

The current study was conducted to determine the prevalence of Helicobacter pylori in the oral cavity of a Chinese population. Nested polymerase chain reaction (PCR) was used to investigate whether individuals with oral H. pylori show more possibility of gastric infection and to examine the relationship between gastric H. pylori infection and the presence of the bacteria in the oral cavity. A total of 443 dyspeptic patients participated in the study. Gastric H. pylori infection was detected by the rapid urease test and histology with Giemsa staining, PCR, or smear examination, whereas the presence of the bacteria in the oral cavity was observed by nested PCR from dental plaque. Relevant periodontal and dental parameters were recorded in the process of oral examination. Of the 443 study patients, oral H. pylori was found in the dental plaque of 263 (59.4%) and the stomach of 273 (61.6%). Additionally, in all four age groups, the prevalence of gastric infection was significantly higher among the patients with positive tests for H. pylori in their dental plaque than in the patients with no H. pylori in their dental plaque (P < 0.05). The oral cavity may be a potential reservoir for H. pylori, and the prevalence of oral H. pylori approximated that of gastric H. pylori in the studied population. Furthermore, a close relationship may exist between H. pylori in the oral cavity and bacteria in the stomach or gastric infection, and dyspeptic patients with gastric infection are more likely to harbor H. pylori in their oral cavity.

Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients

“…Song et al (2000) analysed 117 samples of dental plaque from 42 patients and verified the presence of the bacterium in 68% of the samples. These results are similar to those of Liu et al (2009), who found positive samples in 59% of their subjects. It is interesting to note that these studies differ from the results of Kignel et al (2005), who found a low prevalence in gastric biopsy samples and only one positive dental plaque sample.…”

Prevalence of oral Helicobacter pylori infection in dyspeptic patients with gastric Helicobacter pylori infection

“…We could not study the effect of triple drug regimen on gHP / oHP positivity, but we observed a much higher prevalence of oHP in our study (63.6% vs. 35%). Liu et al (16) conducted nested PCR study on dental plaques and RUT plus antral biopsy for detection of oHP and gHP respectively, in 443 dyspeptic patients. oHP was found in 59.4% and gHP in 61.6 %.…”

A Review of Hemostasis in Normal Pregnancy and Puerperium

“…Another possible mechanism is an increased consumption of platelets inside utero-placental circulation [7,8] accelerating thrombopoiesis in bone marrow. As a result, an increase in mean platelet volume (MPV), platelet distribution width and large-size platelets in peripheral film were observed in many [7,9,17,25] but not all reports [18,26]. Large-sized platelets may be pathogenic [27] but since platelet turnover is usually normal [20] and platelet count is low therefore, overall effect is a balanced platelet mass [7].…”