An epidemiologic study of insect allergy in children. I. Characteristics of the disease

Schuberth, Kenneth C.; Lichtenstein, Lawrence M.; Kagey‐Sobotka, Anne; Szklo, Moysés; Kwiterovich, Kathleen A.; Valentine, Martin D.

doi:10.1016/s0022-3476(82)80750-6

Cited by 74 publications

(32 citation statements)

References 12 publications

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“…The upper limb was the most common area of stings in parallel with previous studies [20,21,22]. Involvement of organ systems, such as the cutaneous system followed by respiratory and gastrointestinal systems, was also consistent with previous childhood data [19,23]. In the meantime, results of our study revealed some significant differences between demographic features of children allergic to wasp and bee venoms.…”

Section: Discussionsupporting

confidence: 91%

“…As a result of spending more time outdoors leading to an increased risk of exposure to insect stings, a male predominance was present in our study population, as shown in previous childhood studies [5,6,7,18,19]. The upper limb was the most common area of stings in parallel with previous studies [20,21,22].…”

Section: Discussionsupporting

confidence: 85%

“…Observation of children with insect allergy has led to the perception of milder clinical presentations with a much higher frequency of isolated cutaneous reactions and a lower frequency of severe cardiovascular symptoms, compared to adults [19,25,26]. Different classifications for defining severe SRs may lead to varying results; however, the frequency of SRs against wasp (56.9%) and bee venom (66.7%) was relatively high in our study population when compared to previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Results of a recent study on British beekeepers revealed female sex as a predisposing factor for severe SR [29]. There are relatively few studies in children, and their results did not establish gender as a risk factor for SR [6,7,19]. In our study, a higher percentage of girls had severe reactions when compared to boys (84.2 vs. 50.9%; p = 0.01), and results of multivariate logistic regression analysis revealed female sex as a significant risk factor for severe SR. To the best of our knowledge, it is a novel finding in children with insect venom allergy.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features of Children with Venom Allergy and Risk Factors for Severe Systemic Reactions

Yavuz

Şahiner²,

Büyüktiryaki³

et al. 2012

Int Arch Allergy Immunol

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Background: Severe systemic reactions (SRs) to insect venom are rare in childhood and there are few data on this study population. The aim of our study is to analyze the clinical features and to document the risk factors for severe SRs in children with insect venom allergy. Methods: Children with SRs after Hymenoptera sting were analyzed. The diagnosis was based on medical history, skin tests and/or specific IgE testing. Results: Seventy-six children were included [57 boys (75%), mean age 9.8 ± 3.4 years]. The mean age of children at the time of SR was 8.3 ± 3.4 years. Reactions were accounted for Vespula (wasp) venom in 58 (76%) and Apis mellifera (bee) venom in 18 (24%) patients. Twenty-six percent of patients had aeroallergen sensitization and 33% had atopic disease, whereas 66% had experienced previous stings. The upper limb was the most frequent area of sting (43%), and the cutaneous system (99%) was the most frequent involved system. SRs occurred in 59% of patients. Multivariate logistic regression analysis revealed eosinophilia (>5%) [odds ratio (OR) 12.6; confidence interval (CI) 1.5–109.7; p = 0.022], female sex (OR 6.4; CI 1.5–26.9; p = 0.011) and accompanying atopic disease (OR 3.4; CI 1.2–12.3; p = 0.016) as significant risk factors for severe SRs. Ninety-seven percent of patients were admitted to the emergency department; however, epinephrine was used in only 46% of patients. Conclusions: There was a high frequency of hypersensitivity to wasp venom among the study population, and severe reactions were related to mild eosinophilia, female sex and concomitant atopic diseases. A better understanding of the risk factors may lead to effective utilization of health care sources in the future.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical Features of Children with Venom Allergy and Risk Factors for Severe Systemic Reactions

Yavuz

Şahiner²,

Büyüktiryaki³

et al. 2012

Int Arch Allergy Immunol

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“…Cutaneous systemic reactions, elsewhere termed Type I or mild systemic reactions, 20,21 are unique in terms of the limited scope of their clinical presentation and improved outcome in younger age groups. 22 Consistent with previous descriptions, 23 children in our population more frequently presented with cutaneous systemic reactions than adults (Figure 1). Guidelines for the acute treatment of cutaneous systemic reactions are not included in the current SIH practice parameter.…”

Section: Discussionsupporting

confidence: 91%

Repeat Epinephrine Treatments For Stinging Insect Hypersensitivity Reactions Presenting To The Emergency Department

Rudders¹,

Katzman²,

Banerji³

et al. 2010

Journal of Allergy and Clinical Immunology

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Epidemiology of Insect Venom Sensitivity

Golden¹

1989

JAMA

216

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The prevalence of insect sting reaction and of venom sensitization in adults is unknown. We report the results of intake evaluation of a stratified random sample of a large adult population previously studied for the determinants of atopic disease. In 269 subjects, the prevalence of systemic allergic sting reactions was 3.3% and 26.5% had IgE antibodies to venom demonstrated by skin test or radioallergosorbent test. Asymptomatic sensitization (positive venom skin test) was observed in 15% of subjects with no history of an allergic sting reaction. Positive venom skin tests were more frequent in men, in those with positive skin tests to inhalant allergens, and in subjects aged 20 through 29 years. A positive venom skin test or radioallergosorbent test was more frequent in subjects who had been stung within the previous 3 years (35%) than in those stung more than 3 years before (20%). We conclude that both systemic allergic reactions to insect stings and asymptomatic sensitivity to venom are common and that most affected persons never seek medical advice. The significance of asymptomatic venom sensitization is unknown.

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An epidemiologic study of insect allergy in children. I. Characteristics of the disease

Cited by 74 publications

References 12 publications

Clinical Features of Children with Venom Allergy and Risk Factors for Severe Systemic Reactions

Clinical Features of Children with Venom Allergy and Risk Factors for Severe Systemic Reactions

Repeat Epinephrine Treatments For Stinging Insect Hypersensitivity Reactions Presenting To The Emergency Department

Epidemiology of Insect Venom Sensitivity

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