An epidemiologic study of inflammatory bowel disease in Rochester, New York

Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001

“…Most studies reported the peak onset of both UC and CD at late puberty -early adulthood period. In some studies a second peak of onset was observed in 50-70 year-olds [25] . The EC-IBD study [8] reported one peak onset in CD in both sexes around the age of 20 (incidence rate in men was around 6.0 and in women 7.7) followed by a continuous decrease.…”

Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin

“…1). 16 Additionally, MDX consumption by preterm piglets lead to the expansion of ileal E. coli populations 17 and induced necrotizing enterocolitis in these animals, but not in fully developed pigs. 18 Increased levels of E. coli and AIEC strains have been repeatedly observed in ileal CD patients, suggesting a role for E. coli in disease pathogenesis.…”

Inflammatory bowel disease: the Indian augury

“…Are we witnessing (a) a reverse incidence of Crohn's disease or (b) a window period in IBD epidemiology where the incidence of CD bypasses the incidence of UC? Initially reported in France [10] and Belgium [11] in the early 1990s, a higher incidence of CD was also observed in Stockholm [12], Manitoba [13], Rochester [14], Cardiff [15], and Tubingen [16]. The inverse ratio could be explained by the stability in incidence of UC, whereas CD had increased in most developed countries.…”