Report of caseRecently, NYU dermatologists have identified two cases of leprosy in New York that have never been outside the United States. The first case of a person never to travel out of the U.S. was a Caucasian chemist from Queens, NY reported in 2000 (1). A more recent case was a black male from the Bronx, New York in 2008 (2). We now report the third proven identified case of leprosy never out of the continental United States.The patient is a 48 year-old Black woman complaining of skin discoloration of the face, hands and legs for one year. On exam she was well-developed appearing in no acute distress; eyes and mucous membranes were normal. Over the right and left posterior calf there were two lichenified plaques and surrounding hypopigmentation and dyschromia of the skin with hypoesthesia. Biopsy was compatible with BL (Figure 1A-D). It is important to order a Fite stain when suspecting leprosy as the Ziehl-Neelsen stain is usually weak, as in this case, and often is negative. Her lab results were within normal ranges. ELISA was performed against M. leprae Ag85B (ML2028), ND-O-HSA (PGL-I) and LepLAM and compared to three LL patient sera (LL8, LL27 and LL32) which are very well characterized to have high reactivity to all three antigens by ELISA and Western blot (Figure 2) (3). The titer for this patient's serum is consistent with BL/LL individuals.