An epidemic or a plague of common mental disorders?

Furukawa, Toshi A

doi:10.1111/acps.13108

Cited by 4 publications

(3 citation statements)

References 10 publications

(10 reference statements)

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“…Health freedom advocates cite increases in the incidences of many chronic illnesses including autoimmune diseases, depression and anxiety disorders, neurodegeneration, autism, learning and behavioral problems, as well as gender identification problems in children, obesity, allergies, diabetes, liver cirrhosis, and chronic fatigue syndrome (CFS). [1][2][3][4] Certain cancers are viewed as not only being more common but growing faster than normal, 5 such that they are sometimes referred to as turbo cancers. Incomplete recovery is occurring in approximately a quarter of those clinically infected with the COVID-19 virus.…”

Section: Introductionmentioning

confidence: 99%

Stealth adapted viruses and the epidemic of chronic illnesses

Martin

2024

JHVRV

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Stealth adapted viruses elude recognition by the cellular immune system due to the loss or mutation of genes coding the relatively few components typically targeted by the cellular immune system. Political barriers to accepting the existence of these viruses arose when it became apparent that some of the viruses had originated from the cytomegaloviruses that commonly infected monkeys used to produce poliovirus vaccines. Many virologists are seemingly unaware of the restricted targeting of viral components by the cellular immune system or that genetically defective viruses can continue to replicate and cause cellular damage. Immunologists may also be somewhat reluctant to acknowledge possible non-immunological virus defense mechanisms. There are growing concerns regarding the increasing incidence of major chronic illnesses. Patient support groups are continually advocating for more research on the cause of specific disease entities. There is also a growing sense that special interests may have unintentionally imposed toxic exposures on the public leading to chronic illnesses. Relief from such exposures is being demanded by various Health Freedom movements. This article is intended to better inform the Health Freedom movements and various chronic illness support groups about the existence of stealth adapted viruses. A broader understanding of these viruses and their incorporated renegade cellular and microbial sequences will facilitate therapeutic endeavors, especially those based on the Alternative Cellular Energy (ACE) pathway.

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Section: Introductionmentioning

confidence: 99%

Stealth adapted viruses and the epidemic of chronic illnesses

Martin

2024

JHVRV

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“…Articles on depression typically commence with such despairing themes, citing dire facts and daunting statistics for society and the depressed (Furukawa 2019). On the one hand, this characterization makes good clinical and humane sense.…”

Section: Introductionmentioning

confidence: 99%

Major Depression and Its Recurrences: Life Course Matters

Monroe

Harkness

2022

Annu. Rev. Clin. Psychol.

166

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Major depression is one of the most prevalent and debilitating personal and public health conditions worldwide. Less appreciated is that depression's tremendous burdens are not shared equally among all who become depressed. Some will suffer recurrences over the rest of their lives, whereas half or more will never have a recurrence. Based on these two distinctive life course prototypes, we propose a subtype distinction for research on the origins and lifetime course of major depression. A pressing goal is to determine at the time of depression's first onset who will follow which clinical trajectory. The lack of recognition of this distinction has resulted in many obstacles, including conceptual biases, methodological oversights, and definitional dead ends. Current theories are reviewed and compared. The implications for contemporary diagnostic controversies, reevaluating research on treatment and prevention, and enhancing the predictive strength of traditionally weak indicators of recurrences and recurrent depression are discussed. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 18 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…However, research over the next 30 years has shown that depression prevention is possible2 and cost-effective 3. In the meantime, however, health losses due to common mental disorders are continuing to increase and depression remains the largest source of disabilities due to mental health worldwide 4 5. Subthreshold depression, that is, a depressive state falling short of meeting the diagnostic threshold for major depression, is more prevalent than major depression itself and leads to major losses in well-being and productivity 6.…”

Section: Introductionmentioning

confidence: 99%

Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhancement with Smartphone in LIving ENvironmenTs): a master protocol

et al. 2023

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IntroductionThe health burden due to depression is ever increasing in the world. Prevention is a key to reducing this burden. Guided internet cognitive–behavioural therapies (iCBT) appear promising but there is room for improvement because we do not yet know which of various iCBT skills are more efficacious than others, and for whom. In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysisBased on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. This app now covers five CBT skills: cognitive restructuring, behavioural activation, problem-solving, assertion training and behaviour therapy for insomnia. The current study is designed as a master protocol including four 2×2 factorial trials using this app (1) to elucidate specific efficacies of each CBT skill, (2) to identify participants’ characteristics that enable matching between skills and individuals, and (3) to allow future inclusion of new skills. We will recruit 3520 participants with subthreshold depression and ca 1700 participants without subthreshold depression, to examine the short-term efficacies of CBT skills to reduce depressive symptoms in the former and to explore the long-term efficacies in preventing depression in the total sample. The primary outcome for the short-term efficacies is the change in depressive symptoms as measured with the Patient Health Questionnaire-9 at week 6, and that for the long-term efficacies is the incidence of major depressive episodes as assessed by the computerised Composite International Diagnostic Interview by week 50.Ethics and disseminationThe trial has been approved by the Ethics Committee of Kyoto University Graduate School of Medicine (C1556).Trial registration numberUMIN000047124.

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An epidemic or a plague of common mental disorders?

Cited by 4 publications

References 10 publications

Stealth adapted viruses and the epidemic of chronic illnesses

Stealth adapted viruses and the epidemic of chronic illnesses

Major Depression and Its Recurrences: Life Course Matters

Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhancement with Smartphone in LIving ENvironmenTs): a master protocol

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