An Epidemic of Histoplasmosis Among School Children in Arkansas

Chin, Tom D. Y.; Ney, Peter E.; Saltzman, Benjamin A.; Paxton, George; Rakich, Jennie H.; Ware, Mildred; Whitmore, Margaret; Furcolow, Michael L.

doi:10.1097/00007611-195608000-00001

Cited by 14 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure in enclosed areas, such as buildings or caves usually causes more severe illnesses than exposure occurring outdoors (16)(17)(18). Also, attack rates are higher when exposure occurs in schools or other areas involving children, as children are less likely than adults to be immune as a result of previous infection (18)(19)(20)(21). Prior infection provides partial imnmnity against reinfection.…”

Section: Historymentioning

confidence: 99%

Diagnosis and management of Histoplasmosis

1989

Eur. J. Clin. Microbiol. Infect. Dis.

View full text Add to dashboard Cite

Histoplasmosis occurs throughout the world but is more common within the endemic areas of North America, particularly in fertile river valleys. Disease manifestations range from asymptomatic infection in the normal host with low-inoculum exposure to rapidly fatal, disseminated infection in the severely immunocompromised host, emphasizing the importance of cellular immunity in defense against Histoplasma capsulatum. Diagnosis depends on a high index of suspicion, knowledge of the clinical and epidemiologic features of the infection, and a thorough understanding of the uses and limitations of fungal cultural and serological laboratory procedures. Recently, a method has been developed for rapid diagnosis based on detection of a polysaccharide antigen in body fluids of patients with histoplasmosis. Amphotericin B remains the preferred treatment for more severe forms of histoplasmosis, particularly in the immunocompromised host, but oral treatment with ketoconazole or newer imidozoles appears to be effective in less severe infections in non-immunocompromised individuals.

show abstract

Section: Historymentioning

confidence: 99%

Diagnosis and management of Histoplasmosis

1989

Eur. J. Clin. Microbiol. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Infectious Diseases

Reimann¹

1957

AMA Arch Intern Med

View full text Add to dashboard Cite

Spectrums of Infectious Disease

Reimann¹

1960

AMA Arch Intern Med

View full text Add to dashboard Cite

Scant attention was paid to graded degrees of severity of infectious diseases in the past. Study was impeded by undeveloped knowledge, lack of exact methods of diagnosis, rigid clinical criteria of the "typical" case, and, during epidemics, by the pressure of the emergency. Inapparent infections were undetectable, and victims of mild attacks usually were ignored or regarded as having some other ailment. After 1868, for example, according to Wunderlich's dictum, typhoid was not typhoid unless fever reached 39.5 C (103.1 F) between the fourth and sixth days. During an epidemic of cholera as late as 1944, victims not dehydrated or in a shock-like state were not regarded as having cholera. Yet brief typhoid was known to Louis, and Koch had described mild cholera in 1892. I have gathered papers from which perti¬ nent information was drawn to form the basis of this essay. Statistics for leprosy, schistosomiasis, or ecchinococcosis requiring a life-time of observation were not encoun¬ tered. Those for syphilis are meager, but for tuberculosis they are better. Almost all the reports cited were made between 1940 and 1960, many of them stimulated by mili¬ tary exigency during World War II and

show abstract

An Epidemic of Histoplasmosis Among School Children in Arkansas

Cited by 14 publications

References 0 publications

Diagnosis and management of Histoplasmosis

Diagnosis and management of Histoplasmosis

Infectious Diseases

Spectrums of Infectious Disease

Contact Info

Product

Resources

About