An epidemic of acute postinfectious glomerulonephritis in Armenia

Sarkissian, Ashot; Papazian, Marina; Azatian, Gayane; Arikiants, Nina; Babloyan, Ara; Leumann, Ernst

doi:10.1136/adc.77.4.342

Cited by 47 publications

(50 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 Our study showed that most patients with AGN were older than 6 years with a boy to girl ratio of 1.4:1. Our subjects were of lower socioeconomic status than those in the study in Benin city.…”

mentioning

confidence: 53%

“…Table 3 shows the similarities and differences of observations between our study and other investigators. 12,13,15,19,21 Patients with AGN have an expanded extracellular fluid volume secondary due to sodium and water retention leading to clinical manifestations of AGN and generalized circulatory congestion. Although circulatory congestion is similar to primary fluid overload, there is no evidence of abnormality in the heart and blood vessel.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The profile of acute glomerulonephritis among Indonesian children

Albar¹,

Rauf²

2016

View full text Add to dashboard Cite

Background Acute glomerulonephritis (AGN) is a form of glom-erulonephritis characterized by sudden and explosive onset of glom-erular injury symptom. It usually occurs after recent infection bygroup A beta-hemolytic streptococcus. AGN among Indonesianchildren seems to be less frequently reported than that among othercountries.Objective To determine the current profile of AGN among Indo-nesian children hospitalized in eleven teaching centers.Methods This was a descriptive, cross-sectional study, based ona review of the standard medical records of 509 children with AGNhospitalized in 11 teaching centers in Indonesia over a five-yearperiod (1997-2002). Data extracted from the medical records con-sisted of history of illness, clinical and laboratory findings, and chestX-rays.Results Age of the patients at the onset of AGN ranged from 2.5 to15 years, with peak age of 8.5 years. The majority (76.4%) wasabove 6 years old with male predominance (58.3%). About 68.9%and 82% of the patients came from low socioeconomic and low edu-cational status families. Antecedent upper respiratory infections wereobserved in 45.8% cases and pyoderma in 31.6%. The diseaseseemed to be more commonly elicited by streptococcal infectionthan by other infections, as proved by an elevated anti-streptolisinO (ASO) titer (66.6%) and decreased C 3 concentrations (60.4%).The frequent clinical features included periorbital edema (76.3%),hypertension (61.8%), and gross hematuria (53.6%). The most preva-lent laboratory findings were microhematuria (99.3%), proteinuria(98.5%), raised erythrocyte sedimentation rate (85.3%). The initialchest X-rays showed pleural effusion (81.6%) and cardiomegaly(80.2%), whereas echocardiogram documented pericardial effusion(81.6%). Acute pulmonary edema (11.5%), hypertensive encepha-lopathy (9.2%), and acute renal failure (10.5%) were frequent com-plications noted in our study.Conclusion Despite no adequate data on throat or skin cul-tures, AGN among Indonesian children seems mostly to bepoststreptococcal AGN as proved by the elevated ASO titerand decrease in serum C 3 concentration

show abstract

mentioning

confidence: 53%

mentioning

confidence: 99%

The profile of acute glomerulonephritis among Indonesian children

Albar¹,

Rauf²

2016

View full text Add to dashboard Cite

show abstract

“…In Rajajee et al study 13 [12][13][14]5 In the present study, at the time of presentation 82.5% of patients had low levels of serum C3 suggesting post infectious glomerulonephritis. Normal C3 at the time of onset of disease was present in 17.5% of patients.…”

supporting

confidence: 45%

Clinical profile and outcome of acute nephritic syndrome in children from a tertiary care centre in south India: a descriptive study

Valiyat

Valoor

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Acute nephritic syndrome (ANS) is major cause of morbidity in developing countries. This study is an attempt to evaluate the clinical characteristics, complications and outcome of acute nephritic syndrome.Methods:This hospital based descriptive study was conducted at a tertiary care hospital in Kerala, South India. 103 children with ANS were analysed. Detailed clinical examination and relevant laboratory investigations were done. These children were followed up for 1 year.Results: Out of 103 patients studied 64% were male and 36% were female. The peak age group was 6 to 8 years. Skin infection was the most common predisposing condition (68.9%). Hypertension was present in 60.1% of patients. 26.2% of patients developed complications. Of these Acute renal failures was the most commonly encountered complication (18.4%). Proteinuria (87.4%) and microscopic hematuria (80.6%) were the most consistent features. 82.5 % patients had low C3 at the time of diagnosis. Majority of patients with low C3 level had positive ASO titre. (p = 0.014). At 3month follow up C3 became normal in 95.2% of patients. At 3 months’ majority of patients with normal C3 had incomplete recovery. (p = 0.010). At the end of 12m, microscopic heamaturia was present in 4 patients, persistent hypertension in 2 patients, 11 patients had proteinuria. These patients are kept under long term follow up.Conclusions:Complications and morbidity is significantly high during the acute phase in ANS. This study highlights the need for long term follow up of these patients.

show abstract

“…DPGN is known to be post-infectious in nature and in majority of cases it is seen following streptococcal infection. In fact in Armenia, tenfold rise was seen in DPGN in children, following sudden deterioration in socioeconomic conditions [9]. Although some decline has been reported in a South Indian hospital [4], two other Indian studies i.e.…”

Section: Discussionmentioning

confidence: 97%

Spectrum of Nephropathies With Special Reference to Primary Glomerulopathies

Deshpande

Munjal

Rai

2000

Medical Journal Armed Forces India

View full text Add to dashboard Cite

A retrospective study was carried out where histopathology records of Department of Pathology, Armed Forces Medical College, Pone were scrutinised covering a period of 10 years. We came across 325 cases of nephropathies. The sample comprised of 92.6% adults and 7.4% children. 79.7% were males and 20.3% were females. The patient population comprised of 35.1 % serving soldiers, 37.8% their family members and 27.1 % not related to Armed Forces. The study is based on only light microscopy findings. It was observed that primary glomerular disease was the commonest entity and comprised of 61.5% of all the nephropathies. Acute diffuse proliferative glomerulonephritis was not only the commonest primary glomerulopathy (23.5%) but the commonest nephropathy as well. The other primary glomerulopathies in descending order of frequency were, membranoproliferative glomerulonephritis (22.5%), mesangioproliferative glomerulonephritis (21.5%), chronic glomerulonephritis (9%), minimal change disease (7.5%), membranous glomerulopathy (7%), focal segmental glomerulosclerosis (5%) and crescentic glomerulonephritis (4%). We had only 14cases (4.3% of all nephropathies) of secondary glomerulopathies, amongst which amyloidosis was the commonest cause. We came across 2 cases (0.6% of all nephropathies) of Alport's syndrome. In the other nephropathies, 22.2% were tubulointerstitial diseases and 5.5% were malignant kidney tumors. In 5.8% renal biopsies, no significant pathology was seen on light microscopy. MJAFI 2000; 56: 125·129

show abstract

An epidemic of acute postinfectious glomerulonephritis in Armenia

Cited by 47 publications

References 18 publications

The profile of acute glomerulonephritis among Indonesian children

The profile of acute glomerulonephritis among Indonesian children

Clinical profile and outcome of acute nephritic syndrome in children from a tertiary care centre in south India: a descriptive study

Spectrum of Nephropathies With Special Reference to Primary Glomerulopathies

Contact Info

Product

Resources

About