An Epidemic Case of Rabbit Hemorrhagic Disease Caused by Rabbit Hemorrhagic Disease Virus 2 （&lt;i&gt;Lagovirus europaeus&lt;/i&gt; GI.2） in Tochigi, Japan

Ueda, Minato; Harahuji, Mei; Shirai, Yukiji; Yoneyama, Shuji; Tosaki, Kaori; Miyazaki, Akira

doi:10.5686/jjzwm.26.53

Cited by 1 publication

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eleven RHD outbreaks were reported between 1998 and 2020 [9–14]. Thus far, genetic characterisation of Japanese strains has been performed using only a partial sequence of the major capsid gene, VP60 [10–13]. In this study, whole-genome sequencing of the Japanese RHDV strains and analysis of viral recombination events, followed by phylogenetic characterisation, were performed to completely understand the genetics of RHDV in Japan.…”

Section: Introductionmentioning

confidence: 99%

“…Eleven RHD outbreaks were reported between 1998 and 2020 [9][10][11][12][13][14]. Thus far, genetic characterisation of Japanese strains has been performed using only a partial sequence of the major capsid gene, VP60 [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…In Japan, RHD was listed as a notifiable disease under the Act on Domestic Animal Infectious Diseases by the Ministry of Agriculture, Forestry and Fisheries in 1998. Eleven RHD outbreaks were reported between 1998 and 2020 [9][10][11][12][13][14]. Thus far, genetic characterisation of Japanese strains has been performed using only a partial sequence of the major capsid gene, VP60 [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetics of the rabbit haemorrhagic disease virus strains responsible for rabbit haemorrhagic disease outbreaks in Japan between 2000 and 2020

Tanikawa

Watanabe

Mikami

et al. 2023

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

Rabbit haemorrhagic disease (RHD) is a highly contagious and fatal disease in rabbits caused by the rabbit haemorrhagic disease virus (RHDV), which includes two genotypes, RHDV-GI.1 and RHDV2-GI.2. RHDVs tend to recombine among different strains, resulting in significant genetic evolution. This study evaluated the genetics of Japanese RHDV strains associated with six outbreaks between 2000 and 2020 using whole-genome sequencing, genomic recombination and phylogenetic analyses. Genomic recombination analysis using near-complete genomic sequences revealed that two Japanese strains detected in 2000 and 2002 were non-recombinant GI.1 (variant RHDVa-GI.1a) strains of different origins, most closely related to strains identified in PR China in 1997 and the USA in 2001, respectively. In contrast, four recent Japanese GI.2 strains detected between 2019 and 2020 were recombinant viruses harbouring structural protein (SP) genes from GI.2 strains and non-SP (NSP) genes from a benign rabbit calicivirus (RCV) strain of genotype RCV-E1-GI.3 (GI.3P–GI.2) or an RHDV G1-GI.1b variant (GI.1bP–GI.2). Phylogenetic analysis based on SP and NSP regions revealed that the GI.1bP–GI.2 recombinant virus detected in Ehime prefecture and the GI.3P–GI.2 recombinant viruses detected in Ibaraki, Tochigi and Chiba prefectures were most closely related to recombinant viruses identified in Australia in 2017 and Germany in 2017, respectively. These results suggested that past RHD outbreaks in Japan did not result from the evolution of domestic RHDVs but rather represented incursions of foreign RHDV strains, implying that Japan is constantly at risk of RHDV incursion from other countries.

show abstract

Section: Introductionmentioning

confidence: 99%