An enzyme-instructed self-assembly system induces tumor acidosis via sequential-dual effect for cancer selective therapy

Zhang, Hao; Wang, Zhilong; Gao, Tongxin; Wang, Zhongyan; Ren, Chunhua; Liu, Jianfeng

doi:10.1016/j.actbio.2023.03.036

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…Our experiments have shown that multiple cell lines can be cultured within the peptide hydrogel with high cell viability, enabling cells to grow into complex morphology. As a result, the peptide hydrogel developed shows great promise as a versatile tool for a variety of biomedical applications, including drug release, drug screening, and tissue engineering. ,− …”

Section: Discussionmentioning

confidence: 99%

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

Deng,

Xie,

Huang

et al. 2024

ACS Appl. Nano Mater.

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Enzyme-instructed self-assembly (EISA) represents a promising approach to generate functional biomaterials with unique properties for biomedical applications. While EISA has been extensively studied in the context of pericellular hydrogel formation for inhibiting cancer cells, its potential in protecting cells during antitumor drug treatment has remained unexplored. In this study, we designed a dualresponsive peptide 1p, which responds to both Ca 2+ and ALP, undergoing dephosphorylation on the cell surface. This process leads to the formation of a protective pericellular hydrogel that effectively shields cells from the harmful effects of anticancer drug cisplatin. Furthermore, our findings highlight the suitability of peptide hydrogel 1 for cell encapsulation and transplantation, thus broadening its potential applications in cell delivery. This study reports a peptide hydrogel capable of safeguarding normal cell during anticancer drug treatment and underscoring the great potential of the peptide hydrogel for diverse biomedical applications.

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Section: Discussionmentioning

confidence: 99%

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

Deng,

Xie,

Huang

et al. 2024

ACS Appl. Nano Mater.

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A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Ding,

Wei,

Fang

et al. 2024

Adv Funct Materials

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Hydrogen sulfide (H2S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming in cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes to the ineffective therapeutic effect of blocking a single pathway. To achieve complete suppression of energy production, an inorganic H2S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca and Zn is constructed for achieving simultaneous interference of OXPHOS and glycolysis. The core–shell ZSZC nanoparticles can break down in the tumor microenvironment. This leads to a sustained H2S release and calcium overload to disrupt the normal functioning of mitochondria by inhibiting the expression of cytochrome c and causing damage to mitochondrial membrane potential. Meanwhile, the presence of Zn2+ hinders the typical process of glycolysis by impeding the functioning of lactate dehydrogenase and glyceraldehyde‐3‐phosphate dehydrogenase. The synchronous interference of OXPHOS and glycolysis hampers the energy supply to cancer cells. Additionally, H2S and calcium overload can expedite tumor necrosis in vivo by inducing cellular acidification and calcification. Therefore, this energy‐blocking strategy will completely deplete the energy reserves of cancer cells and provide new insights for exploring bioenergetic inhibition as a treatment approach.

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Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

Wang,

Luo,

Wang

et al. 2024

Adv Funct Materials

Self Cite

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Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, the reported PST have shown excellent application prospects in combating many major diseases including cancer, cardiovascular disease, infectious disease, autoimmune disease, metabolic disease, and so on. Through thoughtful design, the PST can be fabricated in various forms, including self‐assembled precursor molecules, functional nano‐assemblies, and macroscopic large‐scale hydrogels. The involved peptides in the PST can play different roles, such as serving drug carriers for effective delivery, acting as scaffold materials for cell culture, and functioning as bioactive sequences for treating diseases. In this review, a comprehensive overview of traditional strategies is provided to build PST and emphasize their therapeutic applications for fighting major diseases that pose a threat to human life and health. Moreover, the main challenges of PST in systems design, therapeutic application, and clinical translation are also briefly discussed. It is hoped that this review can arouse much more attention to be paid for PST and promote its practical application in the biomedical field.

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An enzyme-instructed self-assembly system induces tumor acidosis via sequential-dual effect for cancer selective therapy

Cited by 5 publications

References 40 publications

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

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