“…In previous studies, a few methods were developed to detect and monitor antibiotics including CLB such as microbiology assay, enzyme-linked immunosorbent assay (ELISA), 5 high performance liquid chromatography (HPLC), 6,7 liquid chromatography-mass spectrometry (LC-MS), 8 gas chromatography-mass spectrometry (GC-MS), 9 capillary electrophoresis, 10,11 surface plasma resonance 12 and electrochemical 13 methods. However, even though analytical methods such as HPLC, LC-MS and GS-MS are very sensitive and effective, these methods are relatively expensive, time-consuming and unsuitable for on-site monitoring due to the use of large instruments.…”