An Enzymatic Chemical Amplifier Based on Mechanized Nanoparticles

Xue, Min; Zink, Jeffrey I.

doi:10.1021/ja4066317

Cited by 34 publications

(30 citation statements)

References 27 publications

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“…The precise number of hydroxyl groups defined to the number of glucose units makes it possible to establish strong interactions. This responsive host−guest chemistry has attracted significant interest and has been applied in the modification of material surfaces . Therefore, these carbohydrate surfaces were used to form host–guest complexes of ferrocene (guest) and β ‐cyclodextrin (host) moieties (Scheme , Surface 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…This responsive hostÀguest chemistry has attracted significant interest and has been applied in the modification of material surfaces. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] Therefore, these carbohydrate surfaces were used to form host-guest complexes of ferrocene (guest) and β-cyclodextrin (host) moieties (Scheme 2, Surface 5). The ability to form inclusion complexes with organic molecules inside the cavity can be used to generate switchable surfaces.…”

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin – ferrocene host – guest complexes on silicon oxide surfaces

Nietzold

Dietrich

Lippitz

et al. 2016

Surface & Interface Analysis

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Research on carbohydrate‐based interactions with proteins, nucleic acids, or antibodies has gained increased interest in the last years especially in clinical diagnosis or drug development. The efficiency of diagnostic interfaces depends upon the number of probe molecules, e.g., carbohydrates. The control of surface parameters as density and distribution of immobilized carbohydrates is essential for a reliable interaction with protein analytes. A controlled production of biomolecular interfaces can be reached by a stepwise quality control during buildup of these biointerfaces. Here, ß‐amino‐cyclodextrin molecules were attached to amine‐reactive silicon oxide surfaces via click chemistry to construct a model biosensor surface. The amount of surface bound carbohydrates was determined indirectly after chemical derivatization with 4‐(trifluoromethyl)‐benzylamine (TFMBA). Moreover, these surfaces were used to form host–guest complexes of ferrocene (guest) and β‐cyclodextrin (host) moieties to mimic the target binding (sensing) of the model biosensor. Surface chemical analysis of all steps during biosensor construction was performed using X‐ray photoelectron spectroscopy and near‐edge X‐ray absorption fine structure spectroscopy. Our approach widens the possibilities to generate switchable surfaces based on ß‐cyclodextrin surfaces for biosensor applications. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cyclodextrin – ferrocene host – guest complexes on silicon oxide surfaces

Nietzold

Dietrich

Lippitz

et al. 2016

Surface & Interface Analysis

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“…[67] The authors encapsulated am odel enzyme( porcine liver esterase; PLE) in the pores of MSNs and closed the pore openings with ap Hs ensitive, size-selective triphenylene-based nanocap. However, while in such ac ase an amplification would be achieved through the interplay of differentn anodevices, Min et al published an example of an enzymatic chemical amplifier based on only one type of mechanized silica nanoparticle.…”

Section: Other Applications Of Nanomachinesmentioning

confidence: 99%

“…However, while in such ac ase an amplification would be achieved through the interplay of differentn anodevices, Min et al published an example of an enzymatic chemical amplifier based on only one type of mechanized silica nanoparticle. [67] The authors encapsulated am odel enzyme( porcine liver esterase; PLE) in the pores of MSNs and closed the pore openings with ap Hs ensitive, size-selective triphenylene-based nanocap. This nanocap served as ab arrier, keeping the large enzymei nside the pores and al arge "reporter" substrate of the enzyme (5carboxyfluorescein diacetate;CFDA) outside.…”

Section: Other Applications Of Nanomachinesmentioning

confidence: 99%

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

2016

Self Cite

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Many machines (including nanomachines) consist of a solid support with moving parts that can undergo large amplitude motion to carry out specific tasks. In this Minireview, we will describe nanomachines that are supported on mesoporous silica nanoparticles that are typically 50-100 nanometers in diameter and have an array of open, readily accessible pores with an average width of a few nanometers. For triggering a large amplitude motion of the moving parts, we will focus primarily on external stimuli such as heat or light. As for the specific task the machines are carrying out, this Minireview will focus on the controlled release of pharmaceutically active agents in biomedical applications. We will discuss examples of how nanomachines can be used for remotely controlled cargo release and how existing machines that were originally designed to respond to internal physiological stimuli could be reconfigured to respond to external stimuli instead.

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“…Stimuli‐responsive porous materials have attracted substantial research efforts due to their great ability of encapsulation of guest molecules by high surface area and advanced pore structure, as well as controllable releasing of guest molecules by smart molecule gate. By chemical modification of different molecule gates, different stimuli, such as pH, light, ions, and temperature, can trigger the “open” state of pores, leading to on‐command release of entrapped substrates. Among them, stimuli‐responsive DNA‐gated materials, using DNA as molecule gate, which can not only respond to physical and chemical stimuli but also biological stimuli, are wildly utilized in the application of drug delivery, imaging, and biosensing .…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive DNA‐Gated Nanoscale Porous Carbon Derived from ZIF‐8

Cao

Xia

Meng

et al. 2019

Adv Funct Materials

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Stimuli-responsive nanoscale porous carbon derived from ZIF-8 (NCZIF) gated by DNA capping units is reported. The NCZIF is first obtained by calcination of nano-ZIF-8 crystals under an inert atmosphere. It is further conjugated with amine-modified single-stranded DNA after carboxylation (DNA/NCZIF). The guest molecules are sealed in the pore of NCZIF by the formation of a DNA duplex structure on the surface of NCZIF. As proof of principle, two systems that can be, respectively, used for controlled drug delivery and biosensing are introduced. In the first system, the drug model (rhodamine 6G, Rh6G) is locked in the NCZIF by the DNA capping units composed of rich-G sequences and its complementary DNA strand. The in vitro cellular experiments reveal that DNA/NCZIF has good biocompatibility and can controllably release Rh6G upon the K + -stimuli in cells. In the second system, the signal probe (methy lene blue, MB) is locked in the NCZIF and then released after the unlocking of the pores triggered by the dissociation of the aptamer-hybrid capping units. The MB-loaded DNA/NCZIF can linearly respond to target molecules in the range from 1 × 10 −9 to 10 × 10 −6 m and has good specificity.

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An Enzymatic Chemical Amplifier Based on Mechanized Nanoparticles

Cited by 34 publications

References 27 publications

Cyclodextrin – ferrocene host – guest complexes on silicon oxide surfaces

Cyclodextrin – ferrocene host – guest complexes on silicon oxide surfaces

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

Stimuli‐Responsive DNA‐Gated Nanoscale Porous Carbon Derived from ZIF‐8

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