An Enzymatic Basis for the Acceleration of Ciliary Activity by Negative Air Ions

Krueger, A. P.; Smith, Richard

doi:10.1038/1831332a0

Cited by 28 publications

(4 citation statements)

References 5 publications

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“…Related researches have demonstrated that NAIs were effective in decreasing PM2.5 amount [ 10 ]. In biomedical application, Krueger et al [ 11 ] indicated NAIs accelerate tracheal activity in mammals in vitro and in vivo and found that the hemoglobin of animals killed by carbon dioxide recovered its bright red color more quickly in NAIs than in ordinary air. Sirota et al [ 12 ] showed that inhaling NAIs for 60 min at the dosage of 320–350 000 ions/cm 2 in animals activated the respiratory organs by acting directly on mucosal and blood, but their mechanism is unknown.…”

Section: Introductionmentioning

confidence: 99%

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Cheng

Li²,

Yao³

et al. 2022

PLoS ONE

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Negative air ions (NAIs) being bioactive and negative charged molecules may confer antioxidant and anti-inflammatory activity. We assessed the effect of NAIs on two inflammatory diseases in animal models including lipopolysaccharide (LPS) induced acute lung injury (ALI) and wound healing in diabetic rats. We used intra-tracheal infusion of LPS to induce ALI and made a full-thickness cutaneous wound in streptozotocin-induced diabetic female Wistar rats. We evaluated NAIs effects on reactive oxygen species amount, leukocyte infiltration, wound healing rate, western blot, and immunohistochemistry in the lungs of ALI and skin sections of wounds. Our data found NAIs exposed saline displayed higher antioxidant activity vs. non-exposed saline. NAIs exposure did not significantly affect arterial blood pressure and respiratory frequency in control and LPS treated groups. LPS increased leukocyte infiltration, caspase 3/Poly-ADP-ribose-polymerase-mediated apoptosis formation and decreased Beclin-1/LC3-II-mediated autophagy in lungs. NAIs exposure conferred pulmonary protection by depressed leukocyte infiltration and caspase 3/Poly-ADP-ribose-polymerase mediated apoptosis and enhanced LC3-II-mediated autophagy in LPS induced ALI. NAIs treatment resulted in a significantly accelerated wound closure rate, decreased erythrocyte accumulation and leukocyte infiltration mediated oxidative stress and inflammation, and upregulated expression of skin collagen, vascular endothelial growth factor receptor-2 (VEGFR-2) and factor transforming growth factor-beta 1 (TGF-β1) vs non-treated group. Based on these results, it is suggested that NAIs conferred a protection through the upregulating LC3-II-dependent autophagy mechanism and downregulating leukocyte infiltration mediated inflammation and caspase 3/Poly-ADP-ribose-polymerase signaling in the LPS-treated ALI and promoted diabetic wound healing through the enhancing skin collagen synthesis, VEGFR-2 and TGF-β1 pathways.

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Section: Introductionmentioning

confidence: 99%

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Cheng

Li²,

Yao³

et al. 2022

PLoS ONE

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“…Isolated rats exhibited increased emotionality and increased brain serotonin: this effect was reversed, behaviorally and biologically, by ambient anions [ 101 . Cations were also found to reduce ciliary actions and mucus flow in tracheal tissue of rats and rabbits [9,111. The effect was mimicked with injected serotonin and reversed by either reserpine or anions [12].…”

mentioning

confidence: 96%

“…Giannini et al were able to disrupt pheromone goal-directed behavior in the red flour beetle, Triboleum castaneum with a generated ambient cation concentration of 2400/cm3 air, (normal 1050-11 50/cm3 air) [6] . Mice exposed to high concentrations of ambient cations were found to have increased levels of tracheal [7] , brain [8] , and intestinal serotonin [9] . Isolated rats exhibited increased emotionality and increased brain serotonin: this effect was reversed, behaviorally and biologically, by ambient anions [ 101 .…”

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confidence: 99%

Anxiogenic Effects of Generated Ambient Cations—A Preliminary Study

Giannini

Jones

Loiselle

et al. 1987

Int J Psychiatry Med

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“…But During the last 6 years, the effects of air ions per se on mammalian cells and enzyme systems have been investigated in detail (8,9,10,11,12). A mechanism of action has been hypothesized (13) and has received partial experimental confirmation (14).…”

Section: Introductionmentioning

confidence: 99%

Identification & mode of action of a component of positively-ionized air causing enhanced growth in plants

Smith

Fuller

1961

Plant Physiol.

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An Enzymatic Basis for the Acceleration of Ciliary Activity by Negative Air Ions

Cited by 28 publications

References 5 publications

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat

Anxiogenic Effects of Generated Ambient Cations—A Preliminary Study

Identification & mode of action of a component of positively-ionized air causing enhanced growth in plants

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