An environmentally benign cascade reaction of 1,2,3-indantriones with ethyl 2-(pyridine-2-yl)acetates for site-selective synthesis of 5H-isochromeno[4,3-b]indolizin-5-ones

Cu-Catalyzed Oxidative [3 + 2] Annulation of 2-(Pyridine-2-yl)acetates with Maleimides: Synthesis of 1H-Pyrrolo[3,4-b]indolizine-1,3-diones

“…Indolizines are privileged heterocyclic units found in myriad different synthetic and natural products with a variety of biological activities, including anticancer (Y08284) and anticonvulsant, and some have been developed as phosphatase inhibitors (Figure ). Owing to their potential for a providing a broad range of medicinal properties, a plethora of synthetic strategies for efficiently preparing indolizines and their derivatives have been developed. − These strategies can be divided into five categories based on the starting materials from which they are prepared: pyridines, 2-(pyridin-2-yl)­acetates, pyridinium ylides, propargylic pyridines, and others . The strategies based on 2-(pyridin-2-yl)­acetates mainly include oxidative [3 + 1 + 1] annulations and oxidative cross-coupling/cyclization of alkenes and 2-(pyridin-2-yl)­acetates, the latter of which only results in the preparation of simple indolizine derivatives.…”

“…2-(Pyridine-2-yl)­acetate derivatives are also versatile building blocks ,, used in the synthesis of a variety of different heterocycles. In this paper, we reacted 2-(pyridine-2-yl)­acetate derivatives with maleimides through a cascade reaction to test this model reaction in the presence of different catalysts and oxidants.…”