An environmental study on starch aerogel for drug delivery applications: effect of plant scale-up

Marco, Iolanda De; Iannone, Raffaele; Miranda, Salvatore; Riemma, Stefano

doi:10.1007/s11367-017-1351-6

Cited by 35 publications

(28 citation statements)

References 38 publications

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“…Many assumptions and uncertainties are involved in the case of scale-up calculations [108]. Roes and Patel [33] describe the main uncertainties within their analysis comprehensively, whereas, in other studies, no statement is made on the uncertainty of input data or results [32,42,44,45,76,99,[109][110][111]. Several authors address uncertainty with sensitivity analyses to account for parameter variation [22,38,53,60].…”

Section: Uncertaintymentioning

confidence: 99%

How to Conduct Prospective Life Cycle Assessment for Emerging Technologies? A Systematic Review and Methodological Guidance

2020

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Emerging technologies are expected to contribute to environmental sustainable development. However, throughout the development of novel technologies, it is unknown whether emerging technologies can lead to reduced environmental impacts compared to a potentially displaced mature technology. Additionally, process steps suspected to be environmental hotspots can be improved by process engineers early in the development of the emerging technology. In order to determine the environmental impacts of emerging technologies at an early stage of development, prospective life cycle assessment (LCA) should be performed. However, consistency in prospective LCA methodology is lacking. Therefore, this article develops a framework for a prospective LCA in order to overcome the methodological inconsistencies regarding prospective LCAs. The methodological framework was developed using literature on prospective LCAs of emerging technologies, and therefore, a literature review on prospective LCAs was conducted. We found 44 case studies, four review papers, and 17 papers on methodological guidance. Three main challenges for conducting prospective LCAs are identified: Comparability, data, and uncertainty challenges. The issues in defining the aim, functionality, and system boundaries of the prospective LCAs, as well as problems with specifying LCIA methodologies, comprise the comparability challenge. Data availability, quality, and scaling are issues within the data challenge. Finally, uncertainty exists as an overarching challenge when applying a prospective LCA. These three challenges are especially crucial for the prospective assessment of emerging technologies. However, this review also shows that within the methodological papers and case studies, several approaches exist to tackle these challenges. These approaches were systematically summarized within a framework to give guidance on how to overcome the issues when conducting prospective LCAs of emerging technologies. Accordingly, this framework is useful for LCA practitioners who are analyzing early-stage technologies. Nevertheless, further research is needed to develop appropriate scale-up schemes and to include uncertainty analyses for a more in-depth interpretation of results.

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Section: Uncertaintymentioning

confidence: 99%

How to Conduct Prospective Life Cycle Assessment for Emerging Technologies? A Systematic Review and Methodological Guidance

2020

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“…The starch-based aerogels with excellent biocompatibility and biodegradability have been widely used in drug delivery, due to a wide range of sources and the porous structure. [83][84][85] Pawar et al 86 reported a starchbased drug delivery material which was developed by converting native starch from hydrogel to aerogel. This starch-based aerogels improved the dissolution and oral bioavailability of a poorly water-soluble antifungal drug of Itraconazole.…”

Section: Aerogel-based Biomaterials For Drug Deliverymentioning

confidence: 99%

<p>Engineering of Aerogel-Based Biomaterials for Biomedical Applications</p>

Zheng¹,

Zhang²,

Ying³

et al. 2020

IJN

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Biomaterials with porous structure and high surface area attract growing interest in biomedical research and applications. Aerogel-based biomaterials, as highly porous materials that are made from different sources of macromolecules, inorganic materials, and composites, mimic the structures of the biological extracellular matrix (ECM), which is a three-dimensional network of natural macromolecules (e.g., collagen and glycoproteins), and provide structural support and exert biochemical effects to surrounding cells in tissues. In recent years, the higher requirements on biomaterials significantly promote the design and development of aerogel-based biomaterials with high biocompatibility and biological activity. These biomaterials with multilevel hierarchical structures display excellent biological functions by promoting cell adhesion, proliferation, and differentiation, which are critical for biomedical applications. This review highlights and discusses the recent progress in the preparation of aerogel-based biomaterials and their biomedical applications, including wound healing, bone regeneration, and drug delivery. Moreover, the current review provides different strategies for modulating the biological performance of aerogel-based biomaterials and further sheds light on the current status of these materials in biomedical research.

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“…At the same time, adding environmental information in an early development stage is of particular relevance because results can be taken into account by technology developers [18]. Several papers have been published that describe approaches to estimating the environmental impact of emerging photovoltaic cells, chemicals, and aerogels [19][20][21]. Many of these studies focus on developments from the lab/pilot to the industrial scale.…”

Section: Introductionmentioning

confidence: 99%

Potential Carbon Footprint Reduction for Reclaimed Asphalt Pavement Innovations: LCA Methodology, Best Available Technology, and Near-Future Reduction Potential

et al. 2021

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The carbon footprints of asphalt mixtures with increasing reclaimed asphalt pavement (RAP) content were estimated using a life-cycle assessment methodology. Three asphalt mixtures with different applications and technical requirements, namely porous asphalt (PA), stone mastic asphalt (SMA), and asphalt concrete (AC), were included. The technology leaps needed to achieve asphalt mixtures containing up to 93% RAP were modelled. Mixtures containing up to 57% RAP were hot-mix asphalts (175 °C), while mixtures containing more RAP were produced at 135 °C and 105 °C. The energy requirements and their respective carbon footprints were calculated based on the heat capacity of the aggregates, RAP, and other bituminous materials. Furthermore, the effects of changing the country’s electricity mix were also evaluated. A potential carbon footprint reduction of between 55% and 64% was found for one tonne of asphalt containing 93% RAP and produced at 105 °C compared to the 0% RAP mixture produced at 175 °C. Considering the uncertainty of this technology at its early stage of development, the reduction could be as low as 45% or as high as 79%. Changing the electricity mix to one that is likely to be implemented until 2030 in the Netherlands further reduces the footprint by 10%.

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An environmental study on starch aerogel for drug delivery applications: effect of plant scale-up

Cited by 35 publications

References 38 publications

How to Conduct Prospective Life Cycle Assessment for Emerging Technologies? A Systematic Review and Methodological Guidance

How to Conduct Prospective Life Cycle Assessment for Emerging Technologies? A Systematic Review and Methodological Guidance

<p>Engineering of Aerogel-Based Biomaterials for Biomedical Applications</p>

Potential Carbon Footprint Reduction for Reclaimed Asphalt Pavement Innovations: LCA Methodology, Best Available Technology, and Near-Future Reduction Potential

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