An environmental risk assessment for oseltamivir (Tamiflu®) for sewage works and surface waters under seasonal-influenza- and pandemic-use conditions

Straub, Jürg Oliver

doi:10.1016/j.ecoenv.2008.09.011

Cited by 66 publications

(52 citation statements)

References 10 publications

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“…The observed OC concentrations in the STP were very similar to those in three STPs in Kyoto during the 2008/2009 seasonal influenza (Ghosh et al, 2010a). However, the largest OC concentrations in the STP were about 10-fold larger than those reported for wastewater treatment plant influent (42.7 ng/L) in Germany (Prasse et al, 2010), while the concentrations were very small compared to the predicted values for River Lee catchment area (98.1 µg/L) in United Kingdom and western Europe (348.0 µg/L) for pandemic influenza scenario (Straub, 2009 Oseltamivir phosphate in considerably large concentrations was detected in the STP (Fig. 2) for the first time in our knowledge.…”

Section: Results and Discussion Antiviral Drugs In Wastewater And Thementioning

confidence: 73%

“…Widespread detection of antiviral drugs in wastewaters and surface waters particularly during seasonal and pandemic influenza cases (Bartels and Tumpling, 2008;Soderstrom et al, 2009;Prasse et al, 2010;Ghosh et al, 2010a and b;Takanami et al, 2010a), and their potential negative consequences to aquatic ecology and humans (Taylor et al, 2008;Straub, 2009) has recently attracted considerable attention from scientific communities. After administration, the drugs and their metabolites are excreted, carried away in sewers, passed through treatment facilities (Fick et al, 2007;Accinelli et al, 2007Accinelli et al, , 2010aAccinelli et al, , and 2010bSlater et al, 2011) and reached water bodies.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

Takanami

Ozaki

Giri

et al. 2012

J. of Wat. & Envir. Tech.

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Oseltamivir and zanamivir are the two most prescribed antiviral drugs against influenza in Japan. Oseltamivir and its metabolite are frequently detected in surface water bodies in Japan during the last few years particularly in seasonal influenza period posing a potential threat of emergence of drug-resistant genes in human pathogens. Despite the second largest use of zanamivir as an antiviral drug in Japan, its presence and fate in environmental waters is unknown until now. Accurate assessment on the presence and fates of these drugs in environmental waters is the very first step in countering the potential negative impact on human health. We have recently developed a novel solid-phase extraction (SPE) method for simultaneous recovery of oseltamivir and zanamivir in environmental waters. These antiviral drugs were quantified in Neya River water and a nearby conventional sewage treatment plant (STP) during the 2010/2011 seasonal influenza using the SPE method in this investigation. Oseltamivir and zanamivir concentrations in the river water and STP water samples are discussed and compared with those of the 2009/2010 pandemic influenza in this article. This successful simultaneous quantitation of zanamivir in wastewater and river water with high recovery ratios paves the way for its monitoring in environmental waters.

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Section: Results and Discussion Antiviral Drugs In Wastewater And Thementioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

Takanami

Ozaki

Giri

et al. 2012

J. of Wat. & Envir. Tech.

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“…Research reported rather high chronic no-observed effect concentration for oseltamivir and oseltamivir carboxylate (≥1 mg/L) based on ecotoxic tests using traditional aquatic organisms (Hutchinson et al, 2009;Straub, 2009). Acute toxicity of oseltamivir and its carboxylate in traditional aquatic microorganisms was also shown to be less than predicted (Escher et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Peng

Wang

Zhang

et al. 2014

Science of The Total Environment

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“…Importantly, OC is poorly removed or degraded by natural environmental conditions or sewage treatment (21)(22)(23)(24)(25)(26)(27)(28), resulting in significant retention in waterways. These same waterways often support large numbers of waterfowl, the primary reservoir of avian influenza A viruses (AIVs), and waterfowl in several parts of the world are likely exposed over lengthy periods to at least low doses of OC in their drinking water.…”

mentioning

confidence: 99%

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

Achenbach

Bowen

2013

Antimicrob Agents Chemother

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Oseltamivir carboxylate (OC) has been detected in environmental waters at various levels during recent influenza seasons in humans, reflecting levels of usage and stability of this drug. In consideration of the role of waterfowl as hosts for influenza viruses that may contribute to human infections, we evaluated the effect of consumption of low doses of OC on development of oseltamivir-resistant influenza virus mutants in mallard ducks (Anas platyrhynchos) infected with two different low-pathogenic (LP) H5N2 avian influenza viruses (AIV). We detected development of virus variants carrying a known molecular marker of oseltamivir resistance (neuraminidase E119V) in 4 out of 6 mallards infected with A/Mallard/Minnesota/182742/1998 (H5N2) and exposed to 1,000 ng/liter OC. The mutation first appeared as a minor population on days 5 to 6 and was the dominant genotype on days 6 to 8. Oseltamivir-resistant mutations were not detected in virus from ducks not exposed to the drug or in ducks infected with a second strain of virus and similarly exposed to OC. Virus isolates carrying the E119V mutation displayed in vitro replication kinetics similar to those of the wild-type virus, but in vivo, the E119V virus rapidly reverted back to wild type in the absence of OC, and only the wild-type parental strain was transmitted to contact ducks. These results indicate that consumption by wild waterfowl of OC in drinking water may promote selection of the E119V resistance mutation in some strains of H5N2 AIV that could contribute to viruses infecting human populations.

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An environmental risk assessment for oseltamivir (Tamiflu®) for sewage works and surface waters under seasonal-influenza- and pandemic-use conditions

Cited by 66 publications

References 10 publications

Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

Antiviral Drugs Zanamivir and Oseltamivir Found in Wastewater and Surface Water in Osaka, Japan

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Effect of Oseltamivir Carboxylate Consumption on Emergence of Drug-Resistant H5N2 Avian Influenza Virus in Mallard Ducks

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