An entropy–elastic gelatin-based hydrogel system

Tronci, Giuseppe; Neffe, Axel T.; Pierce, Benjamin F.; Lendlein, Andreas

doi:10.1039/c0jm00883d

Cited by 93 publications

(114 citation statements)

References 81 publications

(45 reference statements)

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“…Samples described J-shaped stress-compression curves (data not shown), similar to the case of native tissues. Here, shape recovery was observed following load removal up to nearly 50% compression, suggesting that the established covalent network successfully resulted in the formation of an elastic material, as observed in linear biopolymer networks [15].…”

Section: Network Architecture and Macroscopic Properties Of Collagen mentioning

confidence: 82%

Structure-property-function relationships in triple-helical collagen hydrogels

et al. 2012

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In order to establish defined biomimetic systems, type I collagen was functionalised with 1,3-Phenylenediacetic acid (Ph) as aromatic, bifunctional segment. Following investigation on molecular organization and macroscopic properties, material functionalities, i.e. degradability and bioactivity, were addressed, aiming at elucidating the potential of this collagen system as mineralization template. Functionalised collagen hydrogels demonstrated a preserved triple helix conformation. Decreased swelling ratio and increased thermo-mechanical properties were observed in comparison to state-of-the-art carbodiimide (EDC)-crosslinked collagen controls.Ph-crosslinked samples displayed no optical damage and only a slight mass decrease (~ 4 wt.-%) following 1-week incubation in simulated body fluid (SBF), while nearly 50 wt.-% degradation was observed in EDC-crosslinked collagen. SEM/EDS revealed amorphous mineral deposition, whereby increased calcium phosphate ratio was suggested in hydrogels with increased Ph content. This investigation provides valuable insights for the synthesis of triple helical collagen materials with enhanced macroscopic properties and controlled degradation. In light of these features, this system will be applied for the design of tissue-like scaffolds for mineralized tissue formation.

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Section: Network Architecture and Macroscopic Properties Of Collagen mentioning

confidence: 82%

Structure-property-function relationships in triple-helical collagen hydrogels

et al. 2012

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“…Effect of PACA side chains on the contact angles of PACA-hydrogel multimaterial systemss using heptane as solvent 1 . Uncoated gels showed random pattern with maximum differences in height of 100-200 nm and, as expected for the pure hydrogel, a very minor phase contrast (Fig.…”

Section: Tabmentioning

confidence: 99%

“…It is generally accepted that due to the variety of possible polymer properties depending, e.g., on their composition, architecture, and morphology [1], polymers may be the most feasible and thus most commonly employed class of materials to embed and release drugs. In order to establish combinations of properties and functions that fit the application [2], the tools of macromolecular chemistry can be used to tailor for instance their rate of hydrolysis in aqueous environment in case of degradable materials [3], their mechanical properties, or their capability to interact with water.…”

Section: Introductionmentioning

confidence: 99%

Polyalkylcyanoacrylates as in situ formed diffusion barriers in multimaterial drug carriers

Wischke

Schneider

Neffe

et al. 2013

Journal of Controlled Release

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Polymeric hydrogels typically release their drug payload rapidly due to their high water content and the diffusivity for drug molecules. This study proposes a multimaterial system to sustain the release by covering the hydrogel with a poly(alkyl-2-cyanoacrylate) [PACA]-based film, which should be formed by an in situ polymerization on the hydrogel surface initiated upon contact with water. A series of PACA-hydrogel hybrid systems with increasing PACA side chain hydrophobicity was prepared using physically crosslinked alginate films and hydrophilic diclofenac sodium as model hydrogel/drug system. Successful synthesis of PACA at the hydrogel surface was confirmed and the PACA layer was identified to be most homogeneous for poly(n-butyl-2-cyanoacrylate) on both the micro-and nanolevel. At the same time, the diclofenac release from the hybrid systems was substantially sustained from ~ 1 d for unmodified hydrogels up to >14 d depending on the type of 2 PACA employed as diffusion barrier. Overall, in situ polymerized PACA films on hydrogels may be widely applicable to various hydrogel matrices, different matrix sizes as well as more complex shaped hydrogel carriers.

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“…Gelatin has been explored as a basis for tailorable biopolymer systems. [6][7][8] A hybrid biopolymer containing gelatin as well as chondroitin sulfate was created by functionalizing the two biopolymers with methacrylamide and then crosslinking a mixture of the two functionalized biopolymers using photoirradiation (Van Vlierberghe et al [DOI: 10.1002/masy.201100030]). The storage modulus of the resulting crosslinked biopolymer hybrids was tailorable and varied according to the composition amounts and degrees of methacrylamide substitution (G 0 ¼ 0.1-20 kPa).…”

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confidence: 99%