An enhanced process for encapsulating aspirin in ethyl cellulose microcapsules by solvent evaporation in an O/W emulsion

Yang, C.-Y.; Tsay, Sun-Yuan; Tsiang, Raymond Chien‐Chao

doi:10.1080/026520400288256

Cited by 37 publications

(4 citation statements)

References 9 publications

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“…This may be the reason why Vivek et al [42] demonstrated that incorporating different lipids (glyceryl monostearate, glyceryl tristearate, WE85 and PRE) to produce olanzapine-loaded SLNs using a melt emulsification and high-pressure homogenization method did not have a significant effect on the particle size. In fact, particle size in such studies is determined by the production procedure parameters, such as the surfactant concentration, the organic/aqueous phase ratio, the proportion of different organic solvents and the homogenization speed [44,45]. It has been reported that the most effective factor on the particle size is the effect of the organic/aqueous phase ratio for the solvent diffusion and evaporation method [43].…”

Section: Particle Size Of Nanoparticlesmentioning

confidence: 99%

Targeting etoposide to acute myelogenous leukaemia cells using nanostructured lipid carriers coated with transferrin

2012

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The aim of the present study was to evaluate the diverse properties of transferrin (Tf)-conjugated nanostructured lipid carriers (NLCs) prepared using three different fatty amines, including stearylamine (SA), dodecylamine (DA) and spermine (SP), and two different methods for Tf coupling. Etoposide-loaded NLCs were prepared by an emulsion-solvent evaporation method followed by probe sonication. Chemical coupling of NLCs with Tf was mediated by an amide linkage between the surface-exposed amino group of the fatty amine and the carboxyl group of the protein. The physical coating was performed in a Ringer-Hepes buffer medium. NLCs were characterized by their particle size, zeta potential, polydispersity index, drug entrapment percentage, drug release profiles and Tf-coupling efficiency. The cytotoxicity of NLCs on K562 acute myelogenous leukaemia cells was studied by MTT assay, and their cellular uptake was studied by a flow cytometry method. SA-containing NLCs showed the lowest particle size, the highest zeta potential and the largest coupling efficiency values. The drug entrapment percentage and the zeta potential decreased after Tf coupling, but the average particle size increased. SP-containing formulations released their drug contents comparatively slower than SA- or DA-containing NLCs. Unconjugated NLCs released moderately more drug than Tf-NLCs. Flow cytometry studies revealed enhanced cellular uptake of Tf-NLCs compared to unconjugated ones. Blocking Tf receptors resulted in a significantly higher cell survival rate for Tf-NLCs. The highest cytotoxic activity was observed in the chemically coupled SA-containing nanoparticles, with an IC(50) value of 15-fold lower than free etoposide.

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Section: Particle Size Of Nanoparticlesmentioning

confidence: 99%

Targeting etoposide to acute myelogenous leukaemia cells using nanostructured lipid carriers coated with transferrin

2012

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“…In the realm of controlled drug delivery, several approaches for generating microparticles may be useful. The solvent evaporation method is one of the most frequent ways for preparing microparticles [1][2][3]. Controlling the microparticle preparation processes is critical for achieving the required mean size, size distribution, and shape of microparticles.…”

Section: Introductionmentioning

confidence: 99%

“…Many types of medications, including tiny molecules, proteins, and nucleic acids, can be encapsulated in microparticles. Simple or multiple emulsion procedures such as oilin-water (O/W) or water-in-oil-in-water (W/O/W) are utilized based on the drug's solubility [3][4][5][6]. In the encapsulation and release of pharmaceuticals, the process of microparticle production is a determinant.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Propranolol HCL and Carbamazepine Release Profiles From Poly(є-Caprolactone) Microparticle Blends System

MUHAIMIN,

CHAERUNISAA,

HAZRINA

2023

Int J App Pharm

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Objective: The goal of this research was to look into the physicochemical properties of poly(-caprolactone) microparticle blends that contained medicines of various solubilities (Propranolol HCl [Pro] and carbamazepine [CBZ]). Methods: W/O/W emulsion for Pro and O/W emulsion for CBZ were used to create microparticle blends. With dispersion time intervals (DTI) of 0 and 60 min, the Pro emulsion (W/O) and CBZ oil phase (O) were dispersed in an external aqueous phase (W). Scanning electron microscopy was used to examine the morphology of microparticle blends (SEM). Focused beam reflectance measurements were utilized to monitor the particle size mean of emulsion droplets/hardened microparticles (FBRM). In phosphate buffer (pH 7.4), encapsulation efficiency (EE) and in vitro drug release were also examined. Results: The final microparticle blends generated by solvent evaporation method were spherical and had two populations, according to the findings. The size of microparticle blends prepared with DTI 60 min and stirring duration 4 h was bigger than those prepared with DTI 0 min, according to FBRM data. In microparticle blends, encapsulation efficiency ranged from 62.05±3.74 percent to 66.38±4.16 percent for Pro and 70.56±4.62 percent to 73.85±4.11 percent for CBZ. After 28 d, drug release in phosphate buffer revealed that Pro release (33%) was shorter than CBZ release (60%) from microparticle blends with DTI 60 min. This was related to the interaction of the oil phase (CBZ) with hard particles from the primary emulsion (Pro), in which the oil phase occluded and covered surface structure of the harsh particles from the primary emulsion. Conclusion: Novel microparticle blends comprising drugs/medicines with varying solubilities (e. g. propranolol HCl and carbamazepine) have a lot of promise as controlled-release drug delivery systems. The physical properties of microparticle blends were impacted by the type of dispersion time interval used.

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“…The herbicide norflurazon was encapsulated in ethylcellulose (EC40) microspheres by the solvent evaporation technique to obtain controlled release formulations, which show large encapsulation efficiency for the herbicide [65]. Aspirin were encapsulated with ethylcellulose by oil-in-water emulsification/solvent evaporation technique, The release rate follows first-order kinetics during the first 12 hours, suggesting a monolithic system with aspirin uniformly distributed in the microcapsule [66]. Solvent evaporation method was used to prepare ibuprofen encapsulated ethylcellulose which evidenced the presence of a metastable molecular dispersion for intermediate loadings, coexisting with a solid solution and a crystalline dispersion of the drug in the polymer matrix [67].…”

Section: Encapsulation Using Ethylcellulose As Core Shellmentioning

confidence: 99%

Preparation of fish oil nanospheres for shrimp feeds

Chimpibul

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The aim of this work is to fabricate the encapsulated fish oil particles for shrimp feed. The co-encapsuted fish oil with BHT (Butylated hydroxytoluene as the antioxidant) particles size is 1.00 ± 0.74 mm prepared solvent displacement method using ethylcellulose as the polymeric material. The morphology of these particles were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The encapsulated fish oil-BHT particles were tested to investigate the stability properties. The results indicate that encapsulated fish oil-BHT processes better thermal stability, oxidative stability and shelf life stability than unencapsulated fish oil. Moreover, encapsulated fish oil-BHT particles were added into the shrimp feed to increase the content of unsaturation of polyunsaturated fatty acids (PUFAs) in shrimp diet. The shrimp feeds were prepared with two different methods: 1) mixing encapsulated fish oil-BHT particle to shrimp feed paste for pelting machine before pelleting, 2) spraying encapsulated fish oil-BHT particle suspension onto the shrimp feed pellets. Both methods gave feed with minimal degradation of unsaturation functionality. In addition, Litopenaeus vannamei fed with feed containing the encapsulated fish oil-BHT particle shows better health such as, growth, weight, length and immunity index than those fed with unencapsulated fish oil containing feed.

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An enhanced process for encapsulating aspirin in ethyl cellulose microcapsules by solvent evaporation in an O/W emulsion

Cited by 37 publications

References 9 publications

Targeting etoposide to acute myelogenous leukaemia cells using nanostructured lipid carriers coated with transferrin

Targeting etoposide to acute myelogenous leukaemia cells using nanostructured lipid carriers coated with transferrin

Preparation and Evaluation of Propranolol HCL and Carbamazepine Release Profiles From Poly(є-Caprolactone) Microparticle Blends System

Preparation of fish oil nanospheres for shrimp feeds

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