An enhanced high-resolution EMCCD-based gamma camera using SiPM side detection

Heemskerk, Jan W T; Korevaar, Marc; Huizenga, J.; Kreuger, R.; Schaart, Dennis R.; Goorden, Marlies C; Beekman, Freek J.

doi:10.1088/0031-9155/55/22/011

Cited by 13 publications

(14 citation statements)

References 56 publications

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“…Furthermore, we expect to further improve the detector performance by combining the advantages of silicon photo multipliers (SiPM) with those of EM-CCDs using SiPM side detection (Heemskerk et al 2010). Moreover, we expect that further reduction of the noise in the EM-CCD, for instance by using an advanced CCD controller (Daigle et al 2009), can improve the energy resolution.…”

Section: Discussionmentioning

confidence: 99%

Maximum-likelihood scintillation detection for EM-CCD based gamma cameras

et al. 2011

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Gamma cameras based on charge-coupled devices (CCDs) coupled to continuous scintillation crystals can combine a good detection efficiency with high spatial resolutions with the aid of advanced scintillation detection algorithms. A previously developed analytical multi-scale algorithm (MSA) models the depth-dependent light distribution but does not take statistics into account. Here we present and validate a novel statistical maximum-likelihood algorithm (MLA) that combines a realistic light distribution model with an experimentally validated statistical model. The MLA was tested for an electron multiplying CCD optically coupled to CsI(Tl) scintillators of different thicknesses. For (99m)Tc imaging, the spatial resolution (for perpendicular and oblique incidence), energy resolution and signal-to-background counts ratio (SBR) obtained with the MLA were compared with those of the MSA. Compared to the MSA, the MLA improves the energy resolution by more than a factor of 1.6 and the SBR is enhanced by more than a factor of 1.3. For oblique incidence (approximately 45°), the depth-of-interaction corrected spatial resolution is improved by a factor of at least 1.1, while for perpendicular incidence the MLA resolution does not consistently differ significantly from the MSA result for all tested scintillator thicknesses. For the thickest scintillator (3 mm, interaction probability 66% at 141 keV) a spatial resolution (perpendicular incidence) of 147 µm full width at half maximum (FWHM) was obtained with an energy resolution of 35.2% FWHM. These results of the MLA were achieved without prior calibration of scintillations as is needed for many statistical scintillation detection algorithms. We conclude that the MLA significantly improves the gamma camera performance compared to the MSA.

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Section: Discussionmentioning

confidence: 99%

Maximum-likelihood scintillation detection for EM-CCD based gamma cameras

et al. 2011

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“…These tests are tailored for the assessment of standard LFOV medical gamma cameras currently in clinical use. These typically have a field of view of around 40 cm × 40 cm and resolution ranging from 5-10 mm, whereas SFOV gamma cameras currently in development are achieving resolutions in the order of 0.5 mm [2][3][4]. In some cases, previously described testing methodology can be applied directly to SFOV cameras, however, many tests will require adjustments to remain useful on a smaller scale [5].…”

Section: Jinst 7 P11025mentioning

confidence: 99%

Modelling image profiles produced with a small field of view gamma camera with a single pinhole collimator

2012

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Gamma cameras making use of parallel-hole collimators have a long history in medical imaging. Pinhole collimators were used in the original gamma camera instruments and have been used more recently in dedicated organ specific systems, intraoperative instruments and for small animal imaging, providing higher resolution over a smaller field of view than the traditional large field of view systems.With the resurgence of interest in the use of pinhole collimators for small field of view (SOV) medical gamma cameras, it is important to be able to accurately determine their response under various conditions. Several analytical approaches to pinhole response have been reported in the literature including models of 3D pinhole imaging systems. Success has also been reported in the use of Monte Carlo simulations; however this approach can require significant time and computing power.This report describes a 2D model that was used to investigate some common problems in pinhole imaging, the variation in resolution over the field of view and the use of 'point' sources for quantifying pinhole response.

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“…Furthermore a number of these SiPM units, such as the Philips DPC3200 SiPM [17,18], are four side buttable enabling their tiling to create large surface area MRI compatible radiation detectors ideal for clinical SPECT applications. However at present only a small number of SPECT SiPM radiation detectors has been developed [19,20,21,22], and a single simultaneous acquisition SPECT/MR clinical prototype constructed as part of the INSERT program [23,24].…”

Section: Introductionmentioning

confidence: 99%

In-Silico Optimisation of Tileable Philips Digital SiPM Based Thin Monolithic Scintillator Detectors for SPECT Applications

Brown¹

2019

Preprint

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Over the last decade one of the most significant technological advances made in the field of radiation detectors for nuclear medicine was the development of Silicon Photomultipler (SiPM) sensors. At present a only small number of SiPM based radiation detectors for Single Photon Emission Computed Tomography (SPECT) applications has been explored, and even fewer experimental prototypes developed. An in-silico investigation into the optimal design of a Philips DPC3200 SiPM photosensor based monolithic scintillator detector for SPECT applications was undertaken using the Monte Carlo radiation transport modelling toolkit Geant4 version 10.5. The performance of the 20 different SPECT radiation detector configurations, 4 scintillator materials (NaI(Tl), GAGG(Ce), CsI(Tl) and LYSO(Ce)) and 5 thicknesses (1 to 5 mm), were determined through the use of six different figures of merit. For SPECT/CT applications it was determined that GAGG(Ce) was an optimal scintillator material, with crystal thicknesses of 3 mm and 5 mm being ideal for SPECT/CT systems with pinhole and parallel hole coded apertures respectively. Conversely for SPECT/MR applications it was determine that CsI(Tl) was an optimal scintillator material, with crystal thicknesses of 3 mm and 5 mm again being ideal for SPECT/MR systems with pinhole and parallel hole coded apertures respectively.

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An enhanced high-resolution EMCCD-based gamma camera using SiPM side detection

Cited by 13 publications

References 56 publications

Maximum-likelihood scintillation detection for EM-CCD based gamma cameras

Maximum-likelihood scintillation detection for EM-CCD based gamma cameras

Modelling image profiles produced with a small field of view gamma camera with a single pinhole collimator

In-Silico Optimisation of Tileable Philips Digital SiPM Based Thin Monolithic Scintillator Detectors for SPECT Applications

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