Abstract:BackgroundProgrammed death ligand 1 (PD-L1) and tumor mutation burden (TMB) have been developed as biomarkers for the treatment of immune checkpoint inhibitors (ICIs). However, some patients who are TMB-high or PD-L1-high remained resistant to ICIs therapy. Therefore, a more clinically applicable and effective model for predicting the efficacy of ICIs is urgently needed.MethodsIn this study, genomic data for 466 patients with melanoma treated with ICIs from seven independent cohorts were collected and used as … Show more
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