An enhanced first derivative synchronous spectrofluorimetric method for determination of the newly co-formulated drugs, amlodipine and celecoxib in pharmaceutical preparation and human plasma

Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer’s law in the range of (5–50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified.

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“…The normal probability plot [ 35 ] is another technique for determining if data is normally distributed Fig. 9 .…”

Section: Resultsmentioning

confidence: 99%

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

et al. 2022

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“…Due to the previous characteristics of water molecules, they can completely solvate any polar molecules or even the ions which masks their ability to form strong electrostatic intermolecular interactions (Berg, Tymoczko and Stryer, 2002). An example of the importance of studying partial charges of molecules in their native environment is the dynamic simulation conducted on a system formed of amlodipine and sodium dodecyl sulfate (SDS) to study the complex formation between both of them in a different solvent environment (Attala et al, 2020). In water, it was noticed that AML could not achieve any interactions with SDS due to the effect of the 3-D hydrogen bonding network of water molecules, which buffers the partial charges of both molecules and solvates them completely isolating them from each other, as…”

Section: Pfrosstmentioning

confidence: 99%

Current advances in computer-aided design of electrochemical sensors: An analytical review

Elsonbaty

Attala

Eissa

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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Electrochemical sensors are situated as effective tools for the sensitive and selective determination of several heavy metal traces, pesticides, and a vast diversity of pharmaceuticals in different matrices. The development of advanced electrochemical sensors requires the collaboration of all scientific knowledge especially; computational chemistry, mathematics, and classical and quantum physics. This interdisciplinary in analytical chemistry made it possible to get benefits from molecular modeling, and simulations to develop more selective and sensitive electro-analytical platforms with lowered cost, time, and effort. Recently, the optimization of sensor design was more practical and robust in the light of computational simulation techniques such as molecular docking, dynamics simulation, and quantum calculations. Molecular modeling approaches (MMA) enabled the analyst to explore unrelenting molecular systems ranging from small chemical systems to massive biological molecules and material assemblies in the fields of computational chemistry. Furthermore, MAA has been recently used in the optimization of the design of different electrochemical sensors. Thus, in this review, we went over the different ap-plications of MMA and demonstrate these techniques on both the molecular and quantum levels. Moreover, we focused on the benefits of bringing such innovative techniques to the field of electro-analytical chemistry and highlighted some of the recently reported electrochemical sensors.

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“…A small quantity of SDS may improve the molecular stiffness of drugs under research, leading to a greater fluorescence intensity even at low concentrations. [7] Tramadol (TRM), seen in Figure 1a, is a centrally acting analgesic that works by preventing the uptake of noradrenaline and serotonin by neurons, thereby alleviating pain in some distinct ways. [8] TRM has been previously analyzed using different techniques either alone or with others in different matrices.…”

Section: Introductionmentioning

confidence: 99%

Green micelle and complex inclusion enhance synchronous spectrofluorimetric quantification of a novel analgesic combination: Tramadol and celecoxib in tablet dosage form and spiked human plasma

et al. 2023

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This work offers for the first time an optimized, highly sensitive, simple, and accurate synchronized spectrofluorimetric technique for the simultaneous measurement of tramadol and celecoxib in powder form, their combined multimodal tablet, and finally spiked human plasma samples. Tramadol and celecoxib were recently released as a new drug combination to alleviate intense, sudden pain when other pain medications had failed. The technique entailed taking measurements of the fluorescence amplitudes of the synchronized spectra at Δλ = 100 nm. Excitation was made at 220 nm

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An enhanced first derivative synchronous spectrofluorimetric method for determination of the newly co-formulated drugs, amlodipine and celecoxib in pharmaceutical preparation and human plasma

Cited by 23 publications

References 25 publications

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

Current advances in computer-aided design of electrochemical sensors: An analytical review

Green micelle and complex inclusion enhance synchronous spectrofluorimetric quantification of a novel analgesic combination: Tramadol and celecoxib in tablet dosage form and spiked human plasma

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