An energy-restricted high-protein diet supplemented with β-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: a randomized controlled trial

Haidari, Fatemeh; Hojhabrimanesh, Abdollah; Helli, Bijan; Seyedian, Seyed-Saeed; Angali, Kambiz Ahmadi

doi:10.1016/j.nutres.2019.08.009

Cited by 28 publications

(32 citation statements)

References 46 publications

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“…Only 15 studies of the 19 717 relevant publications evaluated met the inclusion criteria, and contained a total of 28 944 subjects. [11][12][13][14][16][17][18][19][20][21][22][23][24][25][26] These 15 articles included 8 papers analysing differences in the serum carotenoid concentrations between subjects with excess body weight and the normal weight subjects, [19][20][21][22][23][24][25][26] and 7 papers (RCTs) evaluating the change in the anthropometric and blood liquid parameters in response to supplementation with carotenoids. [11][12][13][14][16][17][18] Detailed information and primary outcome parameters are presented in Tables 1 and 2, and the risk of bias within individual studies for RCTs is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…11,12 Nevertheless, some studies have shown that carotenoid interventions have no significant effect on weight change in patients with excess body weight. 13,14 The effect of carotenoids on people with excess body weight is unclear. Consequently, we conducted a meta-analysis of all related observational studies and randomized controlled trials (RCTs) to evaluate the association between carotenoids and overweight or obese subjects.…”

Section: Introductionmentioning

confidence: 99%

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The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis

et al. 2021

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“… 33 There have been many studies of potential non-invasive methods for the early diagnosis of HF, and several serum biomarkers have been identified for use in the diagnosis and staging of HF, including cytokeratin (CK)-18, CK-18 M30 segment, CK-18 M65 and GP73. 34 – 36 In particular, we expect that GP73 will be adopted as a new serological index of HF in chronic liver disease. GP73 is a Golgi membrane protein that is expressed on the surface of epithelial cells and is principally involved in protein secretion, glycosylation and membrane transformation, and has important roles in signal transmission, cell differentiation and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

Yang

et al. 2021

J Int Med Res

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Objective To evaluate the utility of Golgi protein 73 (GP73) in the diagnosis of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging. Methods Ninety-one patients with non-alcoholic fatty liver disease (NAFLD) were allocated to NAFL (n = 46) and NASH (n = 45) groups according to their NAFLD activity score (NAS), and there were 30 healthy controls. Serum GP73 was measured by ELISA, GP73 protein expression was evaluated using immunohistochemistry, and FibroScan was used to determine liver hardness. Results The serum GP73 concentrations of the NAFL and NASH groups were significantly higher than those of controls. GP73 expression in the liver of the patients gradually progressed from absent or low to moderate or high. Serum GP73 positively correlated with liver expression, and the serum and liver GP73 of the patients positively correlated with FibroScan value and HF stage. There was a strong positive correlation of the combination of alanine aminotransferase, gamma glutamyl transferase and GP73 with NASH. The combination of serum GP73 and FibroScan value was found to predict NASH (NAS > 4) and advanced HF (stage ≥2) in patients with NAFLD using receiver operating characteristic analysis. Conclusion Serum GP73 may be useful in the diagnosis of NASH and the staging of HF.

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“…Regarding human studies, a randomized, double-masked, and placebo-controlled clinical trial enrolling subjects suffering non-alcoholic fatty liver disease demonstrated that a BCX capsule for 12 weeks attenuated oxidative stress and inflammatory processes via reduction in MDA and IL-6 serum levels, respectively [310]. Numerous in vitro studies have reported the anticancer activity of β-carotene in gastrointestinal cancers.…”

Section: Human Studiesmentioning

confidence: 99%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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An energy-restricted high-protein diet supplemented with β-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: a randomized controlled trial

Cited by 28 publications

References 46 publications

The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis

The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis

Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

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