An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model

Zhao, Jie; Ouyang, Yi; Wang, Huanhuan; Lai, Huaqing; Hu, Shaowei; Tang, Liying; Yang, Hongjun; Wu, Hongwei

doi:10.1155/2022/3712500

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content. Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40,[43][44][45][46][47][48][49][50]. However, enhanced expression of GGT and MRP1, which are associated with the γ-glutamyl cycle, has been observed in damaged myocardium [33,34,51,52].…”

Section: Metabolism Of Gshmentioning

confidence: 99%

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Tan

Yin

et al. 2023

Cell Death Dis

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The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury. Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury. Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage. Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy. In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches.

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Section: Metabolism Of Gshmentioning

confidence: 99%

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Tan

Yin

et al. 2023

Cell Death Dis

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“…In line with shifted metabolite profiles, mechanism studies indicated the effects of NXT in regulating metabolism associated crucial proteins, including silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), and a subunit of mitochondrial ATP synthase (ATP5D). These results together emphasized the cardioprotective effects of NXT against myocardial infarction, and highlighted the regulatory roles of NXT in energy metabolism related metabolic reprogramming ( Zhao et al, 2022 ). Activated platelets is another crucial risk factor for myocardial infarction occurrence.…”

Section: Pharmacological Propertiesmentioning

confidence: 72%

Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside

Zhang,

Chen,

Tang

et al. 2024

Front. Pharmacol.

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Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT in treating cardiovascular and cerebrovascular diseases (CCVD). Studies have been conducted unceasingly, while this growing latest knowledge of NXT has not yet been interpreted properly and summarized comprehensively. Hence, we systematically review the advancements in NXT research, from its chemical constituents, quality control, pharmacokinetics, to its profound pharmacological activities as well as its clinical applications in CCVD. Moreover, we further propose specific challenges for its future perspectives: 1) to precisely clarify bioactivities of single compound in complicated mixtures; 2) to evaluate the pharmacokinetic behaviors of NXT feature components in clinical studies, especially drug-drug interactions in CCVD patients; 3) to explore and validate its multi-target mechanisms by integrating multi-omics technologies; 4) to re-evaluate the safety and efficacy of NXT by carrying out large-scale, multicenter randomized controlled trials. In brief, this review aims to straighten out a paradigm for TCM modernization, which help to contribute NXT as a piece of Chinese Wisdom into the advanced intervention strategy for CCVD therapy.

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“…Liu et al (2022) used UPLC-IT-TOF-MS/MS to qualitatively analyze the metabolites of berberine in human hepatocellular carcinoma cells to elucidate the biodistribution and pharmacokinetic profile of berberine and its metabolites in hepatocytes. Zhao et al (2022) targeted analysis of 29 kinds of energy metabolites in myocardial tissue based on UPLC-QQ-MS, and verified that Naoxintong Capsules played a role in treating myocardial infarction by affecting part of energy metabolism.…”

Section: Pharmacodynamic Evaluationmentioning

confidence: 79%

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

et al. 2023

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Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.

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An Energy Metabolism Study on the Efficacy of Naoxintong Capsules against Myocardial Infarction in a Rat Model

Cited by 6 publications

References 36 publications

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

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