An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model

Abstract

The LES pressure can be increased using an on-demand microstimulator. The implantation procedure is minimally invasive, represents a novel therapeutic approach to gastroesophageal reflux disease, and may have therapeutic potential for other gastrointestinal motility disorders.

Diagnosis and treatment of benign inflammatory esophageal diseases

“…Clark et al [34] reported a rise in LES pressure in dogs by using an on demand microstimulator, which was implanted endoscopically. Though, 8 mA or more had to be applied to achieve desired pressure increase.…”

Novel Upcoming Therapies

“…The technique has been shown to increase LES resting pressure in animal models [100][101][102]. Human studies, however, focused primarily on patients with EE who are on PPI treatment and have low resting LES pressure as well as abnormal 24-h esophageal acid exposure [103,104].…”

Nonmedical Therapeutic Strategies for Nonerosive Reflux Disease

“…The technique has been shown to increase LES resting pressure in animal models. [51][52][53] Human studies, however, focused primarily on patients with EE who are on PPI treatment and have low resting LES pressure as well as abnormal 24-hour esophageal acid exposure. 54,55 The authors demonstrated that short-term electrical stimulation of the LES improved LES resting pressure, esophageal acid exposure, GERD-HRQL, and PPI consumption without affecting the amplitude of esophageal peristalsis or LES relaxation.…”