An Endodermal Sinus Tumor Diagnosed in Pregnancy: Case Report and Review of the Literature

Elit, L.; Bocking, Alan D.; Kenyon, Cynthia F.; Natale, Renato

doi:10.1006/gyno.1998.5190

Cited by 112 publications

(62 citation statements)

References 20 publications

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“…One child exposed to this regimen was born at 28 weeks of gestation with ventriculomegaly secondary to cerebral atrophy. 4,7 The second was a premature infant born after being treated with bleomycin, etoposide and cisplatin, 7-10 days prior to delivery and developed transient neonatal leucopenia and neutropenia.…”

Section: Discussionmentioning

confidence: 99%

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A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

2009

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Ovarian cancer rarely complicates pregnancy. Usually these malignancies consist of germ cell tumors. Preserving maternal safety along with favorable neonatal outcome is a subject of debate in the management of ovarian cancer during pregnancy. In this report, the authors describe a 25-year-old primigravid woman who was diagnosed to with an ovarian immature teratoma which was diagnosed at 13th weeks of pregnancy during a routine sonography. She underwent oophorectomy at week 21 of her gestation. Then she received three cycles of BEP regimen (bleomycin, etoposide, and cisplatin) during her pregnancy until week 37 of gestation. At 36 weeks she delivered a male baby with mild glandular hypospadia who was otherwise normal. Management of immature teratoma after the first trimester of pregnancy is similar to non-pregnant patients and is safe for both the mother and the fetus.

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Section: Discussionmentioning

confidence: 99%

“…A child born who was exposed to bleomycin and etoposide between 25 to 28 weeks of gestational age developed ventriculomegaly in uteri, and subsequently cerebral atrophy. 4,7 Of other exposed infants, one had alopecia and hearing loss and three had hematologic abnormalities (e.g. anemia, leucopenia, neutropenia and thrombocytopenia).…”

Section: Discussionmentioning

confidence: 99%

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

2009

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“…These agents have also been used previously in pregnant women. Cisplatin has been administered during pregnancy in at least 13 prior published case reports [50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61]. Most of the women were treated for an ovarian malignancy; 1 patient was treated during the first trimester, 10 received chemotherapy during the second and 2 received chemotherapy during the third trimester.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy for a Patient with Advanced Non-Small-Cell Lung Cancer during Pregnancy: A Case Report and a Review of Chemotherapy Treatment during Pregnancy

et al. 2001

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Background: Lung cancer is the most common cause of cancer death in women in the USA. Lung cancer arising during pregnancy is rare and has been reported only 15 times since the 1950s. However, the use of chemotherapy for lung cancer during pregnancy has not previously been reported. Methods: The history, treatment and outcome of a patient with stage IV non-small-cell lung carcinoma (NSCLC) diagnosed during pregnancy is presented. Previous published reports on lung cancer were retrieved by a literature search of Medline and Cancerlit. Results: A 31-year-old woman was diagnosed as having stage IV NSCLC with bilateral pulmonary involvement when 26 weeks pregnant. Her shortness of breath progressed to dyspnea at rest on 100% inspired oxygen. Therefore, she was treated with systemic chemotherapy using cisplatin and vinorelbine. Despite this treatment, her oxygenation declined further over the next 4 days and thus the baby was delivered via cesarean section after 27 weeks of gestation. Four cycles of vinorelbine and cisplatin have now been administered. Following this treatment, the patient has experienced a significant clinical improvement and no longer requires supplemental oxygen. No chemotherapy-related adverse effects have been noted in the baby. In the 15 previously reported patients with concurrent lung cancer and pregnancy, chemotherapy administration during pregnancy has not been described. Conclusions: Treatment of lung cancer with chemotherapy during pregnancy should be considered on an individual basis with regard to the stage of the cancer and the maturity of the fetus. To our knowledge, the case presented here is the first report of a woman receiving chemotherapy for lung cancer while pregnant.

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“…26 Teratogenicity and fetal toxicity included 1 episode of polyhydramnios, 2 episodes of oligoamnios, and 3 episodes of intrauterine growth restriction (the severity of the latter was not reported). In 1 patient, 28 a moderate bilateral ventriculomegaly (15 mm) was diagnosed on ultrasound examination at 26 weeks (AE5 days). In that patient, because the first cycle of cisplatin was administered at 25 weeks (AE5 days), the relation between this malformation and the administration of cisplatin was questionable.…”

Section: Cisplatin and Pregnancymentioning

confidence: 99%

“…The role of cisplatin in the 2 malformations observed at birth remains highly speculative: In 1 patient, 28 a ventriculomegaly was diagnosed during the second trimester, 7 days after the administration of cisplatin; in the other patient, 12 the neonate was diagnosed with microphtalmos after exposure to combination chemotherapy (Dartmouth regimen) during the first trimester. It is noteworthy that microphtalmos is an exceptional malformation, whereas hydrocephalus is observed in up to 2 of 10,000 live births.…”

Section: Teratogenicity Fetotoxicity and Neonatal Outcomementioning

confidence: 99%

Use of platinum derivatives during pregnancy

Mir

Berveiller

Ropert

et al. 2008

Cancer

119

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The incidence of cancer during pregnancy is increasing given the trend for women to postpone childbearing. Knowledge of the potential toxicity and teratogenicity of chemotherapy agents is crucial for patient counseling. Platinum derivatives are active against various malignancies that occur more frequently during pregnancy: melanoma, cervical and ovarian cancers, and lung cancer. The authors of this article performed a systematic review of reports documenting the use of platinum derivatives during pregnancy in the English literature from 1977 through January 2008. Forty-three pregnancies were described: 36 patients received cisplatin, 6 patients received carboplatin, and 1 patient received both drugs. Two fetal malformations occurred after in utero exposure to cisplatin, but the causative link between cisplatin administration and these malformations remains speculative. However, either detectable cisplatin levels or platinum-DNA adducts were observed in neonates who were exposed to platinum derivatives during the third trimester, providing evidence for a late-onset transplacental transfer of these drugs. The administration of platinum derivatives, although feasible during the second and third trimesters of pregnancy, raises concern regarding the transplacental transfer of these drugs in late pregnancy and has unknown short-and long-term effects.

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An Endodermal Sinus Tumor Diagnosed in Pregnancy: Case Report and Review of the Literature

Cited by 112 publications

References 20 publications

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

Chemotherapy for a Patient with Advanced Non-Small-Cell Lung Cancer during Pregnancy: A Case Report and a Review of Chemotherapy Treatment during Pregnancy

Use of platinum derivatives during pregnancy

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