An Enantioselective Synthesis of Spirobilactams through Copper‐Catalyzed Intramolecular Double N‐Arylation and Phase Separation

Abstract

Spirobicyclic structures are versatile building blocks for functional chiral molecules.A ne nantioselective synthesis of chiral spirobilactams via ac opper-catalyzed double Narylation was developed. Amplification of solution ee by in situ precipitation of the racemate was observed with this method and enantioenriched spirobilactams were obtained with excellent ee values through simple solid-solution phase separation.