An empirically based model of the electrically evoked compound action potential

Miller, Charles A.; Abbas, Paul J.; Rubinstein, Jay T.

doi:10.1016/s0378-5955(99)00081-7

Cited by 42 publications

(50 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using our model, we have replicated the following properties within 10% of the reported ( [1]- [4]) feline single-fiber measurements: relative spread (5.8%), spike latency (630 µs), jitter (93 µs), chronaxie (238 µs), relative refractory period (4.6 ms), and conduction velocity (14 m/s). Moreover, we have successfully matched response characteristics of a population of fibers with the same number of diameter-distributed model fibers, enabling us to simulate responses of the entire auditory nerve.…”

Section: Stochastic Population Model For Electricalsupporting

confidence: 70%

Stochastic Population Model for Electrical Stimulation of the Auditory Nerve

Imennov

Rubinstein

2009

IEEE Trans. Biomed. Eng.

Self Cite

View full text Add to dashboard Cite

Abstract-We have developed a biophysical model of a population of electrically-stimulated auditory nerve fibers. It can be used to interpret results from physiological and behavioral experiments with cochlear implants, and to propose novel stimulation strategies. Our model consists of myelinated internodes described by a passive resistor-capacitor network, membrane capacitance and leakage current at the nodes of Ranvier, as well as stochastic representations of nodal voltagedependent channels (Na, K f , and Ks).To approximate physiological properties measured in the auditory nerve (AN) of an acutely deafened cat, electrical parameters of the model fiber were chosen based on literature-reported values. Using our model, we have replicated the following properties within 10% of the reported ([1]-[4]) feline single-fiber measurements: relative spread (5.8%), spike latency (630 µs), jitter (93 µs), chronaxie (238 µs), relative refractory period (4.6 ms), and conduction velocity (14 m/s). Moreover, we have successfully matched response characteristics of a population of fibers with the same number of diameter-distributed model fibers, enabling us to simulate responses of the entire auditory nerve. To demonstrate the performance of our model, we compare responses of a population of ANs stimulated with two speech encoding strategies, Continuous Interleaved Sampling (CIS) and Compressed Analog (CA).

show abstract

Section: Stochastic Population Model For Electricalsupporting

confidence: 70%

Stochastic Population Model for Electrical Stimulation of the Auditory Nerve

Imennov

Rubinstein

2009

IEEE Trans. Biomed. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Overall, the feline functions suggest a general trend for greater spike-rate limitation for higher threshold ANFs, a trend consistent threshold-related adaptation reported by Zhang et al (2007). The broad distribution of ANF rate-level functions is consistent with estimated 12-20 dB ranges of ANF thresholds within the feline auditory nerve (van den Honert and Stypulkowski 1987a;Miller et al 1999b). …”

Section: Relationship Between Ecap Thresholds and Dynamic Ranges Of Anfssupporting

confidence: 80%

“…This study focused on analyses of three measures of ANF responses (spike rate, VS, and F 0 amplitude) and how they varied as functions of time (using the 50 ms epochs) and changes in stimulus level. As noted before, initial spike rate was chosen as a means of assessing stimulus-level effects across a group of ANFs, as fibers will exhibit a range of electric thresholds, presumably due to the across-nerve gradient in stimulus strength and ANF fiber diameter (van den Honert and Stypulkowski 1987a;Miller et al 1999b). Pulse trains were presented repeatedly (typically 30 times) to obtain ANF firing statistics, with a 900-ms silent period between trains.…”

Section: Stimulus Presentationmentioning

confidence: 99%

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

View full text Add to dashboard Cite

Response rates of auditory nerve fibers (ANFs) to electric pulse trains change over time, reflecting substantial spike-rate adaptation that depends on stimulus parameters. We hypothesize that adaptation affects the representation of amplitude-modulated pulse trains used by cochlear prostheses to transmit speech information to the auditory system. We recorded cat ANF responses to sinusoidally amplitude-modulated (SAM) trains with 5,000 pulse/s carriers. Stimuli delivered by a monopolar intracochlear electrode had fixed modulation frequency (100 Hz) and depth (10%). ANF responses were assessed by spike-rate measures, while representation of modulation was evaluated by vector strength (VS) and the fundamental component of the fast Fourier transform (F 0 amplitude). These measures were assessed across the 400 ms duration of pulse-train stimuli, a duration relevant to speech stimuli. Different stimulus levels were explored and responses were categorized into four spike-rate groups to assess level effects across ANFs. The temporal pattern of rate adaptation to modulated trains was similar to that of unmodulated trains, but with less rate adaptation. VS to the modulator increased over time and tended to saturate at lower spike rates, while F 0 amplitude typically decreased over time for low driven rates and increased for higher driven rates. VS at moderate and high spike rates and degree of F 0 amplitude temporal changes at low and moderate spike rates were positively correlated with the degree of rate adaptation. Thus, high-rate carriers will modify the ANF representation of the modulator over time. As the VS and F 0 measures were sensitive to adaptation-related changes over different spike-rate ranges, there is value in assessing both measures.

show abstract

“…Contrary to most data obtained from animal and computer models (Frijns et al 1996;Miller et al 1997Miller et al , 1998Miller et al , 1999bMiller et al , 2001Klop et al 2004;Smit et al 2010), objective and behavioral data from CI users suggest that the anodic polarity is more effective than the cathodic one 2008Undurraga et al 2010Undurraga et al , 2012. However, there are several issues that shall be taken into account from those studies.…”

Section: Introductionmentioning

confidence: 89%

The Polarity Sensitivity of the Electrically Stimulated Human Auditory Nerve Measured at the Level of the Brainstem

Undurraga

Carlyon

Wouters

et al. 2013

JARO

View full text Add to dashboard Cite

Recent behavioral studies have suggested that the human auditory nerve of cochlear implant (CI) users is mainly excited by the positive (anodic) polarity. Those findings were only obtained using asymmetric pseudomonophasic (PS) pulses where the effect of one phase was measured in the presence of a counteracting phase of opposite polarity, longer duration, and lower amplitude than the former phase. It was assumed that only the short high-amplitude phase was responsible for the excitation. Similarly, it has been shown that electrically evoked compound action potentials could only be obtained in response to the anodic phases of asymmetric pulses. Here, experiment 1 measured electrically evoked auditory brainstem responses to standard symmetric, PS, reversed pseudomonophasic, and reversed pseudomonophasic with inter-phase gap (6 ms) pulses presented for both polarities. Responses were time locked to the short high-amplitude phase of asymmetric pulses and were smaller, but still measurable, when that phase was cathodic than when it was anodic. This provides the first evidence that cathodic stimulation can excite the auditory system of human CI listeners and confirms that this stimulation is nevertheless less effective than for the anodic polarity. A second experiment studied the polarity sensitivity at different intensities by means of a loudness balancing task between pseudomonophasic anodic (PSA) and pseudomonophasic cathodic (PSC) stimuli. Previous studies had demonstrated greater sensitivity to anodic stimulation only for stimuli producing loud percepts. The results showed that PSC stimuli required higher amplitudes than PSA stimuli to reach the same loudness and that this held for current levels ranging from 10 to 100 % of the dynamic range.

show abstract

An empirically based model of the electrically evoked compound action potential

Cited by 42 publications

References 26 publications

Stochastic Population Model for Electrical Stimulation of the Auditory Nerve

Stochastic Population Model for Electrical Stimulation of the Auditory Nerve

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

The Polarity Sensitivity of the Electrically Stimulated Human Auditory Nerve Measured at the Level of the Brainstem

Contact Info

Product

Resources

About