Nowadays, for many industries, innovation revolves around two technological improvements, Artificial Intelligence (AI) and machine learning (ML). ML, a subset of AI, is the science of designing and applying algorithms that can learn and work on any activity from past experiences. Of all the innovations in the field of ML models, the most significant ones have turned out to be in medicine and healthcare, since it has assisted doctors in the treatment of different types of diseases. Among them, early detection of breast cancer using ML algorithms has piqued the interest of researchers in this area. Hence, in this work, 20 ML classifiers are discussed and implemented in Wisconsin’s Breast Cancer dataset to classify breast cancer as malignant or benign. Out of 20, 9 algorithms are coded using Python in Colab notebooks and the remaining are executed using the Waikato Environment for Knowledge Analysis (WEKA) software. Among all, the stochastic gradient descent algorithm was found to yield the highest accuracy of 98%. The algorithms that gave the best results have been considered in the development of a novel ensemble model and the same was implemented in both WEKA and Python. The performance of the ensemble model in both platforms is compared based on metrics like accuracy, precision, recall, and sensitivity and investigated in detail. From this experimental comparative study, it was found that the ensemble model developed using Python has yielded an accuracy of 98.5% and that developed in the WEKA has yielded 97% accuracy.