An empirical comparison of univariate versus multivariate methods for the analysis of brain–behavior mapping

Ivanova, Maria V.; Herron, Timothy J.; Dronkers, Nina F.; Baldo, Juliana V.

doi:10.1002/hbm.25278

Cited by 59 publications

(98 citation statements)

References 67 publications

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“…With larger lesions, volume of long associative fibers is more likely to be reduced and, at the same time, more pronounced behavioral deficits are expected. Accordingly, similar to lesion symptom mapping analyses (Ivanova et al, 2021), investigations of tract functionality need to account for lesion volume effects to determine exclusive and differential contribution of tracts to observed deficits.…”

Section: Relationship Between Af Integrity In the Left Hemisphere And Language Abilitiesmentioning

confidence: 99%

Functional Contributions of the Arcuate Fasciculus to Language Processing

Ivanova

Zhong

Turken

et al. 2021

Front. Hum. Neurosci.

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Current evidence strongly suggests that the arcuate fasciculus (AF) is critical for language, from spontaneous speech and word retrieval to repetition and comprehension abilities. However, to further pinpoint its unique and differential role in language, its anatomy needs to be explored in greater detail and its contribution to language processing beyond that of known cortical language areas must be established. We address this in a comprehensive evaluation of the specific functional role of the AF in a well-characterized cohort of individuals with chronic aphasia (n = 33) following left hemisphere stroke. To evaluate macro- and microstructural integrity of the AF, tractography based on the constrained spherical deconvolution model was performed. The AF in the left and right hemispheres were then manually reconstructed using a modified 3-segment model (Catani et al., 2005), and a modified 2-segment model (Glasser and Rilling, 2008). The normalized volume and a measure of microstructural integrity of the long and the posterior segments of the AF were significantly correlated with language indices while controlling for gender and lesion volume. Specific contributions of AF segments to language while accounting for the role of specific cortical language areas – inferior frontal, inferior parietal, and posterior temporal – were tested using multiple regression analyses. Involvement of the following tract segments in the left hemisphere in language processing beyond the contribution of cortical areas was demonstrated: the long segment of the AF contributed to naming abilities; anterior segment – to fluency and naming; the posterior segment – to comprehension. The results highlight the important contributions of the AF fiber pathways to language impairments beyond that of known cortical language areas. At the same time, no clear role of the right hemisphere AF tracts in language processing could be ascertained. In sum, our findings lend support to the broader role of the left AF in language processing, with particular emphasis on comprehension and naming, and point to the posterior segment of this tract as being most crucial for supporting residual language abilities.

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Section: Relationship Between Af Integrity In the Left Hemisphere And Language Abilitiesmentioning

confidence: 99%

Functional Contributions of the Arcuate Fasciculus to Language Processing

Ivanova

Zhong

Turken

et al. 2021

Front. Hum. Neurosci.

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“…Both age and gender were included to account for any systematic relationships to age-related variability in performance and gender-related differences in language localization in the brain ( 52 ). Both of these have been used in previous working memory VLSM studies ( 53 , 54 ). The third covariate was lesion volume that is standardly used in order to avoid the possibility that the locations of VLSM results could be driven by the tendency of large lesions to overlap, spuriously identifying overlapping lesioned voxels as being related to a cognitive process of interest ( 50 ).…”

Section: Methodsmentioning

confidence: 99%

Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory

2021

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Prior behavioral and neuroimaging evidence supports a separation between working memory capacities in the phonological and orthographic domains. Although these data indicate distinct buffers for orthographic and phonological information, prior neural evidence does indicate that nearby left inferior parietal regions support both of these working memory capacities. Given that no study has directly compared their neural substrates based on data from the same individuals, it is possible that there is a common left inferior parietal region shared by both working memory capacities. In fact, those endorsing an embedded processes account of working memory might suggest that parietal involvement reflects a domain-general attentional system that directs attention to long-term memory representations in the two domains, implying that the same neural region supports the two capacities. Thus, in this work, a multivariate lesion-symptom mapping approach was used to assess the neural basis of phonological and orthographic working memory using behavioral and lesion data from the same set of 37 individuals. The results showed a separation of the neural substrates, with regions in the angular gyrus supporting orthographic working memory and with regions primarily in the supramarginal gyrus supporting phonological working memory. The results thus argue against the parietal involvement as supporting a domain-general attentional mechanism and support a domain-specific buffer account of working memory.

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“…In light of recent debates about the superiority of one method over the other, we are confident that the converging evidence from both analyses in our study follows best practice recommendations to exploit specific advantages of either method. 56 …”

Section: Discussionmentioning

confidence: 99%

Dissociable contributions of frontal and temporal brain regions to basic semantic composition

Graessner

Zaccarella

Friederici

et al. 2021

Brain Communications

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Semantic composition is the ability to combine single words to form complex meanings and is an essential component for successful communication. Evidence from neuroimaging studies suggests that semantic composition engages a widely distributed left-hemispheric network, including the anterior temporal lobe, the inferior frontal gyrus and the angular gyrus. To date, the functional relevance of these regions remains unclear. Here, we investigate the impact of lesions to key regions in the semantic network on basic semantic composition. We conducted a multivariate lesion-behaviour mapping study in 36 native German speaking participants with chronic lesions to the language network after left-hemispheric stroke. During the experiment, participants performed a plausibility judgement task on auditorily presented adjective-noun phrases that were either meaningful (‘anxious horse’), anomalous (‘anxious salad’) or had the noun replaced by a pseudoword (‘anxious gufel’), as well as a single-word control condition (‘horse’). We observed that reduced accuracy for anomalous phrases is associated with lesions in left anterior inferior frontal gyrus, whereas increased reaction times for anomalous phrases correlates with lesions in anterior-to-mid temporal lobe. These results indicate that anterior inferior frontal gyrus is relevant for accurate semantic decisions, while anterior-to-mid temporal lobe lesions lead to slowing of the decision for anomalous two-word phrases. These differential effects of lesion location support the notion that anterior inferior frontal gyrus affords executive control for decisions on semantic composition while anterior-to-mid temporal lobe lesions slow the semantic processing of the individual constituents of the phrase.

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An empirical comparison of univariate versus multivariate methods for the analysis of brain–behavior mapping

Cited by 59 publications

References 67 publications

Functional Contributions of the Arcuate Fasciculus to Language Processing

Functional Contributions of the Arcuate Fasciculus to Language Processing

Distinct Neural Substrates Support Phonological and Orthographic Working Memory: Implications for Theories of Working Memory

Dissociable contributions of frontal and temporal brain regions to basic semantic composition

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