2020
DOI: 10.4081/ejh.2020.3155
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An emerging potential therapeutic target for osteoporosis: LncRNA H19/miR-29a-3p axis

Abstract: Osteoporosis (OP) is a complex systemic disease characterized by a loss of bone density, leading to bone fragility and an increase risk of fractures of the hip, spine and wrist. The clinical therapeutic effect is still far from satisfactory. Thus, further studies are urgently needed to explore the pathogenesis of OP. In this study, our aim is to explore the underlying molecular mechanism of lncRNA H19/miR-29a-3p axis for regulating of inflammation, proliferation and apoptosis in OP. The expression of lncRNA H1… Show more

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Cited by 15 publications
(5 citation statements)
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“…It is also a direct target of TF HIF1α, and its expression can be inhibited by miRNA MIR29a [ 130 , 131 ]. Thirdly, TF FOXA1 has been found to bind to E1 enhancer of gene H19 and correlates with lncRNA gene H19 activation [ 132 ]; lncRNA H19 has been shown to suppress miRNA MIR29a [ 133 ]. Remarkably, in an ARDS mouse model induced by LPS, both expressions of FOXA1 and H19 were upregulated.…”
Section: Resultsmentioning
confidence: 99%
“…It is also a direct target of TF HIF1α, and its expression can be inhibited by miRNA MIR29a [ 130 , 131 ]. Thirdly, TF FOXA1 has been found to bind to E1 enhancer of gene H19 and correlates with lncRNA gene H19 activation [ 132 ]; lncRNA H19 has been shown to suppress miRNA MIR29a [ 133 ]. Remarkably, in an ARDS mouse model induced by LPS, both expressions of FOXA1 and H19 were upregulated.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, some contrasting results were reported for the H19 expression in postmenopausal osteoporosis patients. In Xiaoling et al’s research, a significant decrease in H19 was shown [ 59 ], whereas Li et al found significantly a higher expression in this group [ 60 ]. We did not obtain a different H19 expression in patients who suffered from osteoporosis.…”
Section: Discussionmentioning
confidence: 98%
“…MiRNA also exerts a significant effect on the regulation of bone inflammation. For example, Li et al ( Li Z et al, 2020 ) pointed out that miR-29a-3p regulates the inflammatory response of osteoclast to affect the occurrence of osteoporosis. The results of our study demonstrated that miR-27a-3p can act as a suppressor of bone formation and destroy the balance of inflammation in bone tissue.…”
Section: Discussionmentioning
confidence: 99%