An electrostatic focusing ion guide for ion mobility-mass spectrometry

Gillig, Kent J.; Ruotolo, Brandon T.; Stone, Earle G.; Russell, David H.

doi:10.1016/j.ijms.2004.09.005

Cited by 92 publications

(85 citation statements)

References 39 publications

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“…29,33 If the width of the ion packets exceeds the inner diameter of the drift tube prior to its arrival at the IMS terminus, then ions are lost and ion transmission efficiency is reduced. The transmission efficiency through the IMS space alone was assumed to be 100% when Tang et al demonstrated near-perfect ion transfer through an ion funnel interface for ESI-IMS-MS. 34 Sysoev el al also concluded ion loss during transmission through IMS tube was minimal when they obtained similar signals with and without a modular IMS inserted between ESI-MS. 35 Gillig et al simulated ion trajectories inside the drift tube and showed that ions were transferred without any loss through the drift tube when they reported an ion focusing guide for MALDI-IMS-MS. 36 However to our knowledge, no direct empirical data has been reported to demonstrate ion transmission is close to 100% in IMS tube.…”

Section: Ion Transmission In Esi-imsmentioning

confidence: 89%

Characterizing Electrospray Ionization Using Atmospheric Pressure Ion Mobility Spectrometry

2006

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Reduced flow-rate electrospray ionization has been proven to provide improved sensitivity, less background noise, and improved limits of detections for ESI-MS analysis. Miniaturizing the ESI source from conventional electrospray to micro-electrospray and further down to nanoelectrospray has resulted in higher and higher sensitivity. However, when effects of flow rate were investigated for atmospheric pressure ESI-IMS using a nanospray emitter, a striking opposite result was observed. The general tendency we observed in ESI-IMS was that higher flow rate offered higher ion signal intensity throughout a variety of conditions investigated. Thus further efforts were undertaken to rationalize these contradictory results. It is well accepted that decreased flow rate increases both ionization efficiency and transmission efficiency thus improves ion signal in ESI-MS. However, our study revealed that decreased flow rate results in decreased ion signal because ion transfer is constant no matter how flow rate changes in ESI-IMS. Since ion transfer is constant in atmospheric pressure ESI-IMS, ionization efficiency can be studied independently, which otherwise is not possible in ESI-MS where both ionization efficiency and transmission efficiency vary as conditions alter. In this report, we present a systematic study on signal intensity and ionization efficiency at various experimental conditions using ESI-IMS and demonstrated the ionization efficiency as a function of flow rate, analyte concentration, and solvent composition.

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Section: Ion Transmission In Esi-imsmentioning

confidence: 89%

Characterizing Electrospray Ionization Using Atmospheric Pressure Ion Mobility Spectrometry

2006

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“…When a collision occurs, the particle masses and scattering cross sections are calculated by the model code. The hard-sphere models [54,55] were used to determine the post-collisional ion velocity. The columbic repulsion effect was also considered in this model with a factor repulsion method.…”

Section: Cfd-monte Carlo Modeling Approachesmentioning

confidence: 99%

Computational fluid dynamics-Monte Carlo method for calculation of the ion trajectories and applications in ion mobility spectrometry

Han

Cheng

et al. 2012

International Journal of Mass Spectrometry

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“…The renewed interest coincided with technological advances afforded by the analytical refinement of orthogonal TOF instruments [7], efficient transfer of ions from high pressure ion sources to vacuum [8], the development of low-pressure (less than 10 Torr) drift tube designs, which are more easily adapted to high vacuum mass spectrometers and ionization techniques capable of forming intact biomolecular ions. In addition, elevated pressure ion focusing strategies such as electrostatic ion guides [9] or electrodynamic rf fields [10][11][12] have greatly improved the ion transmission of the ion mobility spectrometer, and the recently introduced traveling-wave ion mobility instrument utilizing high resolution orthogonal TOF mass analysis has enormous potential for a broad range of studies from small molecules to macromolecules, includ-ing MDa protein complexes [13]. Despite the development of these novel IM technologies, the traditional uniform field drift tube IM continues to provide the most reliable determinations of ion-neutral collision cross sections and performs with the highest achievable ion mobility resolving powers [14,15].…”

Section: Introductionmentioning

confidence: 99%

A Mass-Selective Variable-Temperature Drift Tube Ion Mobility-Mass Spectrometer for Temperature Dependent Ion Mobility Studies

May

Russell

2011

J. Am. Soc. Mass Spectrom.

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A hybrid ion mobility-mass spectrometer (IM-MS) incorporating a variable-temperature (80-400 K) drift tube is presented. The instrument utilizes an electron ionization (EI) source for fundamental small molecule studies. Ions are transferred to the IM-MS analyzer stages through a quadrupole, which can operate in either broad transmission or mass-selective mode. Ion beam modulation for the ion mobility experiment is accomplished by an electronic shutter gate. The variable-temperature ion mobility spectrometer consists of a 30.2 cm uniform field drift tube enclosed within a thermal envelope. Subambient temperatures down to 80 K are achievable through cryogenic cooling with liquid nitrogen, while elevated temperatures can be accessed through resistive heating of the envelope. Mobility separated ions are mass analyzed by an orthogonal time-of-flight (TOF) mass spectrometer. This report describes the technological considerations for operating the instrument at variable temperature, and preliminary results are presented for IM-MS analysis of several small mass ions. Specifically, mobility separations of benzene fragment ions generated by EI are used to illustrate significantly improved (greater than 50%) ion mobility resolution at low temperatures resulting from decreased diffusional broadening. Preliminary results on the separation of long-lived electronic states of Ti + formed by EI of TiCl 4 and hydration reactions of Ti + with residual water are presented.

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An electrostatic focusing ion guide for ion mobility-mass spectrometry

Cited by 92 publications

References 39 publications

Characterizing Electrospray Ionization Using Atmospheric Pressure Ion Mobility Spectrometry

Characterizing Electrospray Ionization Using Atmospheric Pressure Ion Mobility Spectrometry

Computational fluid dynamics-Monte Carlo method for calculation of the ion trajectories and applications in ion mobility spectrometry

A Mass-Selective Variable-Temperature Drift Tube Ion Mobility-Mass Spectrometer for Temperature Dependent Ion Mobility Studies

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