An electrospun polyurethane scaffold-reinforced zwitterionic hydrogel as a biocompatible device

Liu, Sihang; Ma, Jun; Xu, Liangbo; Lin, Weifeng; Xue, Weili; Mei, Huang; Chen, Shengfu

doi:10.1039/c9tb02870f

Cited by 13 publications

(13 citation statements)

References 53 publications

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“…According to the analysis of the molecular structure of zwitterions by Shao et al [ 11 ], pSBMA hydrogel is more easily strengthened by dipole–dipole interaction, which is attributed to the balanced charge density between anion and cation. PCBMA-pSBMA zwitterionic elastomers hydrogel prepared by Dong et al ( Figure 5 a) [ 47 ], and polyurethane electrospun-pSBMA composite hydrogels prepared by Liu et al [ 50 ] enhanced the dipole–dipole interaction of the SB units by applying additional stress to the pSBMA network, which further enhanced the mechanical strength of zwitterionic hydrogels. In addition, using pSBMA or poly (carboxybetaine acrylamide) (pCBAA) and natural polymers such as alginate to prepare double network hydrogels is also the main method to enhance the mechanical properties of zwitterionic hydrogels ( Figure 5 b) [ 51 ].…”

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

“…It is worth noting that in the design of ordinary double network hydrogels, the second networks composed of flexible polymers often do not add crosslinking agents in the process of preparation but interact with the first network through physical action. However, for zwitterionic polymer, due to the strong hydration of its molecular surface, if the zwitterionic polymer network is not stabilized by crosslinker in a salt solution, the antifouling zwitterionic network will release slowly, resulting in the loss of functionality [ 6 , 44 , 47 , 50 , 53 ].…”

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

“…Zwitterionic materials showed excellent anti-platelets adhesion and biocompatibility. Liu et al [ 50 ] prepared electrospun reinforced SBMA hydrogel with high tensile strength and excellent anti-platelets adhesion. Time-lapse image of coagulation even showed there is no interaction between composite hydrogel and fibrin network during the whole coagulation period ( Figure 14 a).…”

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

“…( a ) Time-lapse image of coagulation showed no interaction between electrospun reinforced zwitterionic hydrogel and fibrin network. Reproduced with permission from [ 50 ]. Copyright 2020 The Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

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Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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“…Although zwitterionic hydrogels have good biocompatibility and respond to stimuli, they lack mechanical strength to be an ideal tissue supporting material in direct contact with blood. This problem was solved in a study done in 2020 by combining Electrospun fiber scaffold to zwitterionic hydrogels to achieve biocompatibility and mechanical strength to make long-term blood contact devices possible [55].…”

Section: Zwitterionic Polymersmentioning

confidence: 99%

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Munguia-Lopez

Cho

et al. 2021

Molecules

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Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.

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In Situ Synthesis of Mechanically Robust, Transparent Nanofiber‐Reinforced Hydrogels for Highly Sensitive Multiple Sensing

Zhang

et al. 2021

Adv Funct Materials

108

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Hydrogels that are both highly conductive and mechanically robust have demonstrated great potential in various applications ranging from healthcare to soft robotics; however, the creation of such materials remains an enormous challenge. This study presents an in situ synthesis strategy for developing bioinspired chemically integrated silica-nanofiber-reinforced hydrogels (SFRHs) with robust mechanical and electronic performance. The strategy is to synthesize soft hydrogel matrices from acrylamide monomers in the presence of well-dispersed silica nanofibers and vinyl silane, which generates homogenous SFRHs with innovative interfacial chemical bonds. The resultant SFRHs exhibit excellent mechanical properties including high mechanical strength of 0.3 MPa at a fracture strain of 1400%, high Young's modulus of 0.11 MPa (comparable to human skin), and superelasticity over 1000 tensile cycles without plastic deformation, while maintaining high transmittance (≥83%). In parallel, the SFRHs show enhanced ionic conductivity (3.93 S m −1 ) and can monitor multiple stimuli (stretching, compressing, and bending) with high sensitivity (gauge factor of 2.67) and ultra-durability (10 000 cycles). This work may shed light on the design and development of tough and stretchable hydrogels for various applications.

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An electrospun polyurethane scaffold-reinforced zwitterionic hydrogel as a biocompatible device

Abstract: An electrospun scaffold-reinforced zwitterionic hydrogel achieved both high tensile strength and mechano-induced self-enhancement while maintaining excellent hemocompatibility.

Cited by 13 publications

References 53 publications

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

In Situ Synthesis of Mechanically Robust, Transparent Nanofiber‐Reinforced Hydrogels for Highly Sensitive Multiple Sensing

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