An electrospun fiber reinforced scaffold promotes total meniscus regeneration in rabbit meniscectomy model

Gao, Shuang; Chen, Mingxue; Wang, Pei; Li, Yan; Yuan, Zhiguo; Guo, Weimin; Zhang, Zengzeng; Zhang, Xueliang; Jing, Xiaoguang; Li, Xu; Liu, Shuyun; Xiang, Sheng; Xi, Tingfei; Guo, Quanyi

doi:10.1016/j.actbio.2018.04.012

Cited by 52 publications

(58 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As with other processing technologies, synthetic polymers are usually more affordable and more convenient to work with, allowing better control and reproducibility, whereas natural materials offer biocompatibility and biomimicry that are crucial for cellular growth and function . A growing number of studies report the utilization of dECM as the base material for the production of electrospun scaffolds for artificial tissue engineering . To allow a stable dECM electrospinning process, the dECM solution should be made spinnable, i.e., to possess certain viscoelastic properties and to denature the protein tertiary chain conformations .…”

Section: Decm Processing Approachesmentioning

confidence: 99%

“…Our group has recently suggested an alternative approach to manipulate the microstructural properties of cardiac dECM materials using electrospinning technology . Compared to the production of a native dECM patch, this technology allows better control over construct properties and can be effectively upscaled.…”

Section: Applications Of Processed Decm‐based Materialsmentioning

confidence: 99%

“…The use of tissue‐derived decellularized extracellular matrices (dECM) has been dated back to the beginning of the 20th century, and was since followed and improved by an increasing number of groups revealing the endless potential of this unique biomaterial, isolated from the heart, liver, pancreas, brain, bone, small intestinal submucosa, and urinary bladder, among other tissues . Numerous dECM‐based products have been successfully translated into the clinic for a myriad of medical applications, as has been excellently reviewed elsewhere …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Processed Tissue–Derived Extracellular Matrices: Tailored Platforms Empowering Diverse Therapeutic Applications

Krishtul

Baruch

Machluf

2019

Adv Funct Materials

View full text Add to dashboard Cite

Tissue-derived decellularized extracellular matrices (dECM) have gradually become the gold standard of scaffolds for tissue engineering, owing to their close mirroring of the intricate composition, architecture, and topology of the native extracellular matrix (ECM). Intriguingly, further manipulation of these acellular tissues through various processing techniques has been demonstrated to be an effective strategy to control their characteristics and impart them with ample valuable new traits, thereby expanding their applicability to a significantly wider spectrum of research and translational applications. Herein, state-of-the-art processed dECM platforms and their potential applications are focused on. The ECM characteristics that make it so appealing for tissue engineering are presented, followed by a concise discussion on the main considerations for choosing a dECM source for such applications. The key methodologies for dECM processing, including hydrogel production, bioprinting, electrospinning, and production of porous scaffolds, microcarriers, and microcapsules, as well as their inherent advantages and challenges, are introduced. To demonstrate the use of processed dECM platforms for tissue engineering, selected in vivo and in vitro applications recently developed utilizing these platforms are highlighted. Finally, concluding remarks and a prospective outlook for future developments and improvements in the field of processed dECM-based devices are given.

show abstract

Section: Decm Processing Approachesmentioning

confidence: 99%

Section: Applications Of Processed Decm‐based Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Processed Tissue–Derived Extracellular Matrices: Tailored Platforms Empowering Diverse Therapeutic Applications

Krishtul

Baruch

Machluf

2019

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Por isto, alguns estudos escolhem materiais naturais (38,42) como o colágeno(48) e a seda (18,22). Um dos métodos para a produção de scaffold de matriz extracelular é o processo de descelularização de meniscos (1,19,25,27,29,44,58). Estes dispositivos irão oferecer uma estrutura regenerada similar ao tecido natural(25) mas, com propriedades mecânicas limitadas (9).…”

Section: Metodologiaunclassified

“…Estes dispositivos irão oferecer uma estrutura regenerada similar ao tecido natural(25) mas, com propriedades mecânicas limitadas (9). Para contornar este problema, adição de materiais ou de outros métodos de processamentos podem ser empregadas ao menisco descelularizado (1,58).…”

Section: Metodologiaunclassified