An electrospun citric acid modified polyvinyl alcohol scaffold for vascular tissue engineering

Abstract

The main aim of this study is to fabricate an electrospun citric acid modified polyvinyl alcohol polyester that is biodegradable with non-toxic by-products and can be used for the culture of vascular smooth muscle cells. In this study, we have optimized the conditions for the electrospinning process of this polyester. The fibre morphology was studied by scanning electron microscopy which indicated that the fibre diameter was optimum at a range of 200 to 700 µm at 5% concentration and flow rate of 0.3 mL/h. The membranes were characterized for the change in structural aspects at the molecular level. The results showed development of more crystalline domains on electrospinning. The surface characteristics were also explored. Cell culture studies confirmed that the electrospun scaffold supported the attachment and proliferation of smooth muscle cells, which was evident from the cell proliferation assay. Hence, the electrospun polyester scaffolds are non-toxic and biocompatible with vascular smooth muscle cells, and find promising potential as scaffolds for vascular tissue engineering.

A review on carboxylic acid cross‐linked polyvinyl alcohol: Properties and applications

“…Similarly, CA cross‐linked PVA electrospun was used for the muscle cell culture. [ 99 ] Cross‐linked PVA film was found less hydrophilic hence more cytophilic than virgin PVA film when studied for contact angle. The film was found nontoxic and a good supporting material for the muscle cell culture.…”

Facile Cell-Friendly Hollow-Core Fiber Diffusion-Limited Photofabrication

“…Poor processability and uncontrollable mechanical properties of native polymers limit their application scope in tissue engineering. A number of synthetic polymers, such as polylactic acid ( Savioli Lopes et al, 2012 ), poly(lactic-co-glycolic acid ( Castillo-Dalí et al, 2015 ), and modified polyvinyl alcohol ( Velutheril Thomas and Nair, 2019 ) have been proposed to realize tunable mechanical and biodegradability properties. However, poor biocompatibility of these synthetic materials remains their main drawback.…”