An electrophysiological study of odour similarities of homologous substances

Døving, Kjell B.

doi:10.1113/jphysiol.1966.sp008022

Cited by 55 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response patterns of single cells to various odorants either in the gaseous phase or in the aqueous one were studied in the olfactory bulb by many investigators (SHIBUYA et al, 1962;DOVING, 1965DOVING, , 1966aDOVING et al 1974;HARA, 1967HARA, , 1975HIGASHINO et al, 1969;MATHEWS 1972a, b;TANABE et al, 1975;SHIBUYA et al, 1977). In the present experiment, odorous substances of the same concentrations were applied in the gaseous and aqueous phases, and the stimulative effects were compared.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of the Olfactory Epithelium with Odorants in Gaseous and Aqueous Phases

Iino

Takagi

1978

Jpn.J.Physiol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Stimulation of the Olfactory Epithelium with Odorants in Gaseous and Aqueous Phases

Iino

Takagi

1978

Jpn.J.Physiol

View full text Add to dashboard Cite

show abstract

“…Changes in hydrocarbon structure, especially in carbon chain length, allow facile comparisons between odorant structure and either neural activity or behavior (Döving, 1966;Mori et al, 1992;Imamura et al, 1992;Sato et al, 1994;ComettoMuñ iz et al, 1998;Laska and Teubner, 1998;Laska et al, 1999;Johnson et al, 1999;Malnic et al, 1999;Rubin and Katz, 1999). In the present study, we exposed animals to the five odorants shown in Table 1.…”

mentioning

confidence: 95%

Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration

2000

View full text Add to dashboard Cite

To study the mechanism whereby odorants are encoded in the nervous system, we studied the glomerular-layer activity patterns in the rat olfactory bulb evoked by closely related odorants from different chemical families. These odorants had a common straight-chain hydrocarbon structure, but differed systematically in their functional groups. Neural activity was mapped across the entire glomerular layer by using the ¿(14)C2-deoxyglucose method. Group responses were averaged and compared by using data matrices. The glomerular activity patterns that resulted from this analysis were comprised of modules. Unique combinations of modules were activated by each odorant, demonstrating what may be part of the neural code for odorants. Most of the modules were clustered together in the bulb, perhaps providing for enhanced contrast between related chemicals by means of lateral inhibition. We also determined whether changes in odorant concentration would affect spatial patterns of glomerular activity. Two odorants, pentanal and 2-hexanone, evoked different patterns at increased concentrations, with additional glomeruli being recruited at a great distance from glomeruli in which activity was evoked at lower concentrations. Humans report that both of these odorants change in perceived odor with increasing concentration. Three other odorants (pentanoic acid, methyl pentanoate, and pentanol) did not recruit new areas of glomerular activation with increasing concentration, and humans do not report a changed odor across concentrations of these odorants. The results suggest that changes in modular glomerular activity patterns could underlie altered odor perception across odorant concentrations, and they provide additional support for a combinatorial, spatially based code in the olfactory system.

show abstract

“…Because very closely related chemicals evoke the perception of distinct odors, it remains necessary to address how such similar odorants are coded by the mammalian nervous system. A powerful choice for such studies involves homologous series of odorants differing by single steps of carbon chain length but possessing the same functional chemical group (Döving, 1966;Mori et al, 1992;Imamura et al, 1992;Sato et al, 1994). By using homologous series of aliphatic acids and other aliphatic carbonyl-containing compounds, individual mitral/tufted cells in the dorsomedial rabbit olfactory bulb were found to be tuned to odorants possessing a limited range of carbon chain lengths Imamura et al, 1992).…”

mentioning

confidence: 99%

Multidimensional chemotopic responses to n‐aliphatic acid odorants in the rat olfactory bulb

et al. 1999

View full text Add to dashboard Cite

In an effort to understand the means by which similar chemical odorants are encoded in the mammalian brain, we exposed rats to a homologous series of n-aliphatic acids and mapped the response of the entire olfactory bulb glomerular layer by using a high-resolution [14C]-2-deoxyglucose uptake technique. We found that these similar odorants evoked spatially clustered but distinct responses in the bulb that changed systematically with carbon chain length. In addition to these chemotopic responses, different odorants within the series evoked systematic differences along two other dimensions: amount of deoxyglucose uptake and extent of the glomerular layer showing high activity. Increases along these two dimensions also were correlated with increasing carbon number. The focal glomerular responses were mirrored by responses in deeper bulb layers. Decreasing the odorant concentration decreased the deoxyglucose uptake within focal regions. The focal regions of activity occurred in pairs involving both medial and lateral representations in the bulb, perhaps reflecting the paired medial and lateral projections of olfactory sensory neurons expressing specific types of odorant feature receptor proteins. The observed spatial pattern of response also may explain both the failure of some bulb lesions to interfere with behavioral olfactory responses and the success of other lesions in blocking olfactory responses. These data support a model of parallel, distributed processing of odorants along multiple dimensions. They also support the notion that analyses of the spatial relationships among odorant responses in the olfactory bulb can demonstrate aspects of the mechanism for odor chemical coding.

show abstract

An electrophysiological study of odour similarities of homologous substances

Cited by 55 publications

References 14 publications

Stimulation of the Olfactory Epithelium with Odorants in Gaseous and Aqueous Phases

Stimulation of the Olfactory Epithelium with Odorants in Gaseous and Aqueous Phases

Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration

Multidimensional chemotopic responses to n‐aliphatic acid odorants in the rat olfactory bulb

Contact Info

Product

Resources

About